Document Detail


Repigmentation of leukotrichia in vitiligo with non-cultured cellular grafting.
MedLine Citation:
PMID:  21790525     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Vitiligo in hair-bearing areas is often associated with leukotrichia. Repigmentation of leukotrichia has been reported mainly with tissue and follicular hair grafts. Objectives:  This study aims to evaluate the repigmentation response of leukotrichia after non-cultured cellular grafting. Methods:  We retrospectively reviewed patients with stable generalised and segmental vitiligo who underwent non-cultured cellular grafting from March 2008 to November 2010 in areas with leukotrichia. Percentage of repigmentation of white hairs was based on clinical assessment and standardised digital photography, and was graded "poor", "fair", "good" or "excellent", corresponding to a scale of 0% to 100% repigmentation with respective intervals of 25%. Results:  Eighty-four patients with vitiligo underwent cellular grafting, out of which 13 had grafting in areas with leukotrichia. Twelve patients (92%) had poor repigmentation of leukotrichia 3 months after transplant. One patient defaulted follow-up after this period. At 6-month, fair repigmentation was achieved in 8 out of 12 remaining patients (67%). After 9 to 12 months, however, 91% (n=10) of patients achieved good or excellent repigmentation. One patient did not reach the 9-month follow-up period at the time of data analysis. Leukotrichia of eyebrows yielded excellent repigmentation in 8 out of 9 patients, whereas hairs on the limbs and scalp showed good repigmentation in 2 out of 2 patients at 9 to 12 months. Conclusions:  Good to excellent repigmentation of leukotrichia can be achieved with non-cultured cellular grafting, obviating the need for hair transplantation.
Authors:
E Y Gan; N van Geel; B K Goh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-25
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 British Association of Dermatologists.
Affiliation:
National Skin Centre, Singapore Department of Dermatology, Ghent University Hospital, Ghent, Belgium.
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