Document Detail


Repetitive usage testing with budesonide in experimental nickel--allergic contact dermatitis in individuals hypersensitive to budesonide.
MedLine Citation:
PMID:  11453905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Contact allergy to topical corticosteroids on patch testing is well recognized, but the clinical significance is uncertain. OBJECTIVES: To determine the clinical relevance of contact allergy to topical corticosteroids. METHODS: Seven patients hypersensitive to both budesonide and nickel repeatedly applied budesonide, betamethasone valerate or the common base for both corticosteroids to areas of experimentally induced nickel dermatitis. Nineteen controls allergic to nickel, but not budesonide went through the same procedure. RESULTS: Seventy-one per cent of the budesonide-allergic individuals experienced distant ipsilateral flares of toxicoderma-like eruptions, in addition to a severe deterioration of the experimental dermatitis treated with budesonide, i.e. increased erythema, and abundant papules and vesicles. The areas of dermatitis in all of the 19 controls healed uneventfully. CONCLUSIONS: The clinical relevance of a contact allergy to budesonide was thus substantiated.
Authors:
M Isaksson; M Bruze
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of dermatology     Volume:  145     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-16     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  38-44     Citation Subset:  IM    
Affiliation:
Department of Occupational and Environmental Dermatology, Malmö University Hospital, SE-205 02 Malmö, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Aged
Anti-Inflammatory Agents / adverse effects*
Budesonide / adverse effects*
Dermatitis, Allergic Contact / diagnosis,  etiology*,  pathology
Double-Blind Method
Drug Administration Schedule
Female
Glucocorticoids
Humans
Middle Aged
Nickel
Patch Tests
Severity of Illness Index
Skin Tests / methods
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glucocorticoids; 51333-22-3/Budesonide; 7440-02-0/Nickel; 7786-81-4/nickel sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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