| Repetitive lumbar punctures as treatment for normal pressure hydrocephalus. | |
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MedLine Citation:
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PMID: 19713705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Selected normal pressure hydrocephalus (NPH) patients cannot be treated by shunt operation because of the procedure's high complication rate. We have treated cases in which prolonged clinical improvement of NPH was experienced after one or two lumbar punctures (LPs). We evaluated the predictors of prolonged improvement of NPH symptoms by repeated LP. Thirty-one NPH patients were retrospectively evaluated (age 72.5 +/- 5.8 years). Gait disturbance, urinary incontinence, and cognitive impairment were semiquantified. We divided the patients into three groups (non-responders, temporary responders, and prolonged responders) according to their responses after LP. We analyzed the characteristics of the groups. Gait disturbance (p = 0.046) and urinary incontinence (p = 0.040) scores and total NPH symptom score (p = 0.007) after cerebrospinal fluid drainage were more significantly improved in prolonged responders than in temporary responders. On multiple logistic regression analyses, total NPH score improvement was the only predictor of the prolonged responders (p = 0.03, odds ratio 0.148). Our study showed that some NPH patients could maintain favorable courses for at least 1 year after LP without shunt operation. Repeated LP could be an alternative treatment in selected NPH patients. |
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Authors:
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T S Lim; S W Yong; S Y Moon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-27 |
Journal Detail:
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Title: European neurology Volume: 62 ISSN: 1421-9913 ISO Abbreviation: Eur. Neurol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-09 Completed Date: 2009-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 293-7 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Neurology, Ajou University School of Medicine, Yeongtong-Gu, Suwon, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Humans Hydrocephalus, Normal Pressure / therapy* Magnetic Resonance Imaging Male Patient Selection Predictive Value of Tests Regression Analysis Retrospective Studies Severity of Illness Index Spinal Puncture* Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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