Document Detail


Repetitive hyperpnoea causes peripheral airway obstruction and eosinophilia.
MedLine Citation:
PMID:  10489829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hyperpnoea of canine peripheral airways with dry air results in airway obstruction, mucosal damage, and inflammation. The purpose of this study was to evaluate the effect of repeated dry air challenge (DAC) on airway obstruction, reactivity and the development of airway inflammation in dogs. Canine peripheral airways received DAC (delivered under general anaesthesia through a bronchoscope) every 48 h for two weeks. Peripheral airway resistance and reactivity were measured prior to each DAC. After the final DAC, bronchoalveolar lavage fluid (BALF) cells and soluble mediators from challenged and control airways were measured. Repeated bronchoscopy had no effect on airway mechanics. Repeated DAC produced cumulative increases in peripheral airway resistance and peak obstructive response to DAC. The response to hypocapnia was also increased in airways receiving repeated DAC. However, when the response to agonists was expressed as a change from baseline, consistent significant increases were not observed. Repeated bronchoscopy produced insignificant changes in BALF cells and eicosanoid mediators. Repeated DAC produced marked eosinophilic inflammation and increased prostaglandins D2, E2, and F2alpha, as well as leukotrienes C4-E4. In conclusion, repeated dry air challenge in dogs in vivo causes persistent airway obstruction and inflammation not unlike that found in human asthma.
Authors:
M S Davis; A N Freed
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The European respiratory journal     Volume:  14     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Affiliation:
Dept of Environmental Health Sciences, The Johns Hopkins University, Baltimore, MD 21205, USA.
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MeSH Terms
Descriptor/Qualifier:
Airway Obstruction / etiology*,  pathology,  physiopathology
Airway Resistance
Animals
Bronchoalveolar Lavage Fluid / cytology
Bronchoscopy
Disease Models, Animal
Dogs
Eosinophils / pathology
Hyperventilation / complications*,  pathology,  physiopathology
Hypocapnia / complications,  pathology,  physiopathology
Leukocyte Count
Pulmonary Eosinophilia / etiology*,  pathology,  physiopathology
Recurrence
Grant Support
ID/Acronym/Agency:
ES03819/ES/NIEHS NIH HHS; HL07534/HL/NHLBI NIH HHS; HL51930/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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