Document Detail

Repetitive hydatidiform mole with different male partners.
MedLine Citation:
PMID:  10525376     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to determine the role of parental factors that may relate to the pathogenesis of molar pregnancy. METHODS: A retrospective review of six patients who had a molar pregnancy with at least two different partners at New England Trophoblastic Disease Center between 1965 and March 1999 was performed. RESULTS: A total of 34 pregnancies with 20 different partners were observed in 6 patients. These pregnancies resulted in 15 (44.1%) hydatidiform moles, 8 (23.5%) term live births, 7 (20.6%) therapeutic abortions, 3 (8.8%) spontaneous abortions, and 1 preterm delivery. While 5 patients had a molar pregnancy with 2 different partners, 1 patient had a molar pregnancy with 3 different partners. Two patients developed persistent postmolar gestational trophoblastic tumor in 3 (20.0%) of the 15 episodes of molar pregnancy. Three of the male partners reported a total of 7 healthy children from prior relationships. CONCLUSION: The experience in these six patients suggests that a primary oocyte problem may contribute to the development of molar pregnancy.
Z S Tuncer; M R Bernstein; J Wang; D P Goldstein; R S Berkowitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecologic oncology     Volume:  75     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-04-05     Completed Date:  2000-04-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-6     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Gillette Center for Women's Cancers, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.
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MeSH Terms
Hydatidiform Mole / epidemiology*
Retrospective Studies
Sexual Partners*
Uterine Neoplasms / epidemiology*

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