Document Detail

Repetitive Pupil Light Reflex: Potential Marker in Alzheimer's Disease?
MedLine Citation:
PMID:  25024346     Owner:  NLM     Status:  Publisher    
It was investigated whether alterations of the pupil's light reflex might reflect Alzheimer's disease (AD) pathology. Changes in the pupil's system might be expected due to AD pathology present in the oculomotor system of the Edinger-Westphal nucleus, and a cholinergic deficit caused by degeneration of the nucleus basalis Meynert. A rather new method of repetitive light stimulation was applied assessing variations in pupil size, latency, and amplitude over time. We analyzed 44 healthy controls, 42 subjects with mild cognitive impairment (MCI), and 66 AD patients. AD and MCI showed a less pronounced pupil size decrease and amplitude increase over time than controls. A higher MMSE was associated with a higher increase of relative amplitude and greater decrease of latency in AD and MCI, and absolute amplitude increase in AD alone. Pupil size increase correlated with cerebrospinal fluid markers in AD. Summarized pupil light reflex is not stable under repetitive stimulation, but changes systematically and less pronounced in AD and MCI. Thus repetitive stimulation of the pupil's response potentially indicates AD pathology.
Daniel M Bittner; Isabel Wieseler; Helmut Wilhelm; Matthias W Riepe; Notger G Müller
Related Documents :
11801266 - The eye as metronome of the body.
9039006 - Eye and gonad: role in the dual-oscillator circadian system of female japanese quail.
1938166 - The effects of unilateral forced nostril breathing on cognition.
18310126 - Sex differences in energetic costs explain sexual dimorphism in the circadian rhythm mo...
22936146 - Study of the noise spectrum on high frequency thresholds in workers exposed to noise.
1633746 - Light adaptation and the luminance-response function of the cone electroretinogram.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-11
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  -     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Validation of a Serum Screen for Alzheimer's Disease Across Assay Platforms, Species, and Tissues.
Next Document:  Long-Term Cannabidiol Treatment Prevents the Development of Social Recognition Memory Deficits in Al...