Document Detail


Repetitive convulsant-induced seizures reduce the number but not precision of hippocampal place cells.
MedLine Citation:
PMID:  22442080     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Repetitive one-per-day seizures induced in otherwise normal rats by the volatile convulsant flurothyl decrease the accuracy of locating a hidden goal without changing the mean location of goal selection. We now show that an 8-d series of such seizures degrades the spatial signal carried by the firing of hippocampal pyramidal cells and specifically reduces the information conveyed by the place cell subset of pyramidal cells. This degradation and a concomitant slowing of the hippocampal theta rhythm occur over time courses parallel to the development of the behavioral deficit and plausibly account for the impairment. The details of how pyramidal cell discharge weakens are, however, unexpected. Rather than a reduction in the precision of location-specific firing distributed evenly over all place cells, the number of place cells decreases with seizure number, although the remaining place cells remain quite intact. Thus, with serial seizures there is a cell-specific conversion of robust place cells to sporadically firing (<0.1 spike/s) "low-rate" cells as opposed to gradual loss of place cell resolution. This transformation occurs in the absence of significant changes in the discharge rate of hippocampal interneurons, suggesting that the decline in the number of place cells is not a simple matter of increased inhibitory tone. The cumulative transformation of place cells to low-rate cells by repetitive seizures may reflect a homeostatic, negative-feedback process.
Authors:
Hai Lin; Balázs Hangya; Steven E Fox; Robert U Muller
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-23     Completed Date:  2012-05-18     Revised Date:  2013-08-29    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4163-78     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, The Robert F. Furchgott Center for Neural and Behavioral Science, State University of New York, Brooklyn, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects
Animals
Brain Mapping
Brain Waves / drug effects,  physiology
Convulsants / adverse effects*
Disease Models, Animal
Drug Administration Schedule
Electrodes, Implanted
Electroencephalography
Fasting / physiology
Flurothyl / adverse effects*
Hippocampus / pathology*
Male
Models, Neurological
Neurons / classification,  drug effects*,  physiology
Rats
Rats, Long-Evans
Seizures / chemically induced*,  pathology*
Statistics, Nonparametric
Time Factors
Grant Support
ID/Acronym/Agency:
NS20464/NS/NINDS NIH HHS; R01 NS020686/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Convulsants; 333-36-8/Flurothyl
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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