Document Detail

Reperfusion with streptokinase of an occluded right coronary artery: effects on early and late right and left ventricular ejection fraction.
MedLine Citation:
PMID:  3544753     Owner:  NLM     Status:  MEDLINE    
The effect of coronary artery recanalization on early and late right and left ventricular function was studied in patients with an acute inferior wall myocardial infarction caused by an occlusion of the right coronary artery. Fifty-four out of 138 patients, with chest pain lasting less than 4 hours, with ST elevations diagnostic for acute myocardial infarction not responding to medical treatment, and without contraindication for thrombolytic therapy, had an occluded right coronary artery. In 26 of these 54 patients, the occlusion was located proximal to the first right ventricular branch. Fourteen of them were treated conventionally (group A) and 12 with intracoronary streptokinase (group B). In 28 patients, the occlusion was distal to the first right ventricular branch. Fifteen were treated conventionally (group C) and 13 with intracoronary streptokinase (group D). In all patients, coronary angiograms were made 2 to 3 weeks after acute myocardial infarction. A nuclear angiogram was made the second day after admission and 3 months later to determine right and left ventricular ejection fraction. Values of radionuclide left and right ventricular ejection fraction (RVEF) between acute study (less than 48 hours after acute myocardial infarction [AMI]) and late study (3 months after AMI) showed no significant improvement in the four groups of patients studied. Group A patients (patients with total occlusion of the right coronary artery treated conventionally) had a significantly lower RVEF acutely and at late study as compared to the other three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
S H Braat; M Ramentol; S Halders; H J Wellens
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  113     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-03-06     Completed Date:  1987-03-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-60     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Coronary Circulation / drug effects*
Follow-Up Studies
Heart Catheterization
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology
Prospective Studies
Random Allocation
Streptokinase / pharmacology,  therapeutic use*
Stroke Volume / drug effects*
Time Factors
Reg. No./Substance:
EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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