Document Detail


Reperfusion therapy for STEMI: is there still a role for thrombolysis in the era of primary percutaneous coronary intervention?
MedLine Citation:
PMID:  23953386     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
In the past ten years, primary percutaneous coronary intervention (PCI) has replaced thrombolysis as the revascularisation strategy for many patients presenting with ST-segment elevation myocardial infarction (STEMI). However, delivery of primary PCI within evidence-based timeframes is challenging, and health-care provision varies substantially worldwide. Consequently, even with the ideal circumstances of rapid initial diagnosis, long transfer delays to the catheter laboratory can occur. These delays are detrimental to outcomes for patients and can be exaggerated by variations in timing of patients' presentation and diagnosis. In this Series paper we summarise the value of immediate out-of-hospital thrombolysis for STEMI, and reconsider the potential therapeutic interface with a contemporary service for primary PCI. We review recent trial data, and explore opportunities for optimisation of STEMI outcomes with a pharmacoinvasive approach.
Authors:
Anthony H Gershlick; Adrian P Banning; Aung Myat; Freek W A Verheugt; Bernard J Gersh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  382     ISSN:  1474-547X     ISO Abbreviation:  Lancet     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  624-32     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Affiliation:
Leicester Cardiovascular Biomedical Research Unit, University of Leicester, University Hospitals of Leicester NHS Trust, Glenfield Hospital, Leicester, UK. agershlick@aol.com
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
FS/11/70/28917//British Heart Foundation; //Department of Health

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