Document Detail


Reperfusion strategy after regional ischaemia: comparative study of reperfusion conditions and compositions.
MedLine Citation:
PMID:  15174223     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effects of pressure, temperature and additives on aortic root reperfusion success. Cardiopulmonary bypass and heart arrest were initiated in mongrel dogs and sudden uncontrolled normothermic (group 1), pressure controlled substrate enriched normothermic (group 2a), pressure controlled unmodified normothermic (group 2b) and pressure controlled unmodified tepid (group 3) reperfusion compared. In group 1, the first cardiac rhythm was ventricular fibrillation, but dogs in the other groups showed spontaneous sinus rhythm. Recovery times were significantly longer and cardiac output levels significantly decreased in group 1 compared with the other groups. Prolonged lactate production and oxygen uptake failure were observed in group 1 compared with the other groups; oxidative stress markers and microscopic studies confirmed significant tissue injury in group 1. All parameters were similar between groups 2a, 2b and 3, indicating that low reperfusion pressure in the first 2 min is the most effective component of reperfusion.
Authors:
N T Oğuş; M H Us; H Oğuş; O Y Oztürk; O Işik
Related Documents :
17627183 - N-terminal probrain natriuretic peptide predicts altered circadian variation in essenti...
1042433 - The physiological effects of inhaling exhaled cigarette smoke in relation to attitude o...
1469093 - Gas exchange by intratracheal insufflation in a ventilatory failure dog model.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  32     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2004 May-Jun
Date Detail:
Created Date:  2004-06-03     Completed Date:  2004-12-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  292-303     Citation Subset:  IM    
Affiliation:
Cardiovascular Surgery Department, Maltepe University Faculty of Medicine, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Body Temperature
Dogs
Female
Heart Arrest, Induced
Hemodynamics
Male
Myocardial Ischemia / pathology*
Myocardial Reperfusion / methods*
Myocardial Reperfusion Injury / pathology*
Myocardium / metabolism,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MR...
Next Document:  Reperfusion strategy after regional ischaemia: simulation of emergency revascularization and effects...