| Reperfusion pulmonary edema. | |
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MedLine Citation:
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PMID: 2644456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reperfusion following lower-torso ischemia in humans leads to respiratory failure manifest by pulmonary hypertension, hypoxemia, and noncardiogenic pulmonary edema. The mechanism of injury has been studied in the sheep lung lymph preparation, where it has been demonstrated that the reperfusion resulting in pulmonary edema is due to an increase in microvascular permeability of the lung to protein. This respiratory failure caused by reperfusion appears to be an inflammatory reaction associated with intravascular release of the chemoattractants leukotriene B4 and thromboxane. Histological studies of the lung in experimental animals revealed significant accumulation of neutrophils but not platelets in alveolar capillaries. We conclude that thromboxane generated and released from the ischemic tissue is responsible for the transient pulmonary hypertension. Second, it is likely that the chemoattractants are responsible for leukosequestration, and, third, neutrophils, oxygen-derived free radicals, and thromboxane moderate the altered lung permeability. |
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Authors:
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J M Klausner; I S Paterson; J A Mannick; R Valeri; D Shepro; H B Hechtman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 261 ISSN: 0098-7484 ISO Abbreviation: JAMA Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-03-13 Completed Date: 1989-03-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1030-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Abdominal / surgery Aortic Aneurysm / surgery* Free Radicals Humans Ischemia / physiopathology* Leukotrienes / physiology Lung / pathology Pulmonary Edema / physiopathology* Reperfusion Injury / pathology, physiopathology* Thromboxanes / physiology |
| Grant Support | |
ID/Acronym/Agency:
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GM24891-10/GM/NIGMS NIH HHS; HL16714-13/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/Leukotrienes; 0/Thromboxanes |
| Comments/Corrections | |
Comment In:
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JAMA. 1990 Oct 24-31;264(16):2076
[PMID:
2214074
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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