Document Detail


Reperfusion pulmonary edema.
MedLine Citation:
PMID:  2644456     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reperfusion following lower-torso ischemia in humans leads to respiratory failure manifest by pulmonary hypertension, hypoxemia, and noncardiogenic pulmonary edema. The mechanism of injury has been studied in the sheep lung lymph preparation, where it has been demonstrated that the reperfusion resulting in pulmonary edema is due to an increase in microvascular permeability of the lung to protein. This respiratory failure caused by reperfusion appears to be an inflammatory reaction associated with intravascular release of the chemoattractants leukotriene B4 and thromboxane. Histological studies of the lung in experimental animals revealed significant accumulation of neutrophils but not platelets in alveolar capillaries. We conclude that thromboxane generated and released from the ischemic tissue is responsible for the transient pulmonary hypertension. Second, it is likely that the chemoattractants are responsible for leukosequestration, and, third, neutrophils, oxygen-derived free radicals, and thromboxane moderate the altered lung permeability.
Authors:
J M Klausner; I S Paterson; J A Mannick; R Valeri; D Shepro; H B Hechtman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  JAMA : the journal of the American Medical Association     Volume:  261     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-13     Completed Date:  1989-03-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1030-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Abdominal / surgery
Aortic Aneurysm / surgery*
Free Radicals
Humans
Ischemia / physiopathology*
Leukotrienes / physiology
Lung / pathology
Pulmonary Edema / physiopathology*
Reperfusion Injury / pathology,  physiopathology*
Thromboxanes / physiology
Grant Support
ID/Acronym/Agency:
GM24891-10/GM/NIGMS NIH HHS; HL16714-13/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Leukotrienes; 0/Thromboxanes
Comments/Corrections
Comment In:
JAMA. 1990 Oct 24-31;264(16):2076   [PMID:  2214074 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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