| Reperfusion injury. | |
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MedLine Citation:
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PMID: 8774798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reperfusion injury, precipitated by lack of oxygen, is likely to play a major role in many clinical conditions, including shock, coronary artery occlusion disease, and solid organ transplantation. Certain tissues, such as the intestinal mucosa, may be especially susceptible because of the specific microvascular anatomy. Structural changes include not only swelling of the organelles but also the entire cell due to the entry of water and electrolytes. Lysosomal ruptures precede cell death. Other key substances which either participate in or are part of oxygen free radical formation in tissue injury are calcium ions, leukocytes, and bacteria. Leukocyte adhesion has been implicated as a critical step in vascular endothelium injury, leading to increased microvascular permeability and thrombosis. Induction of neutropenia or the administration of antileukocyte adhesion monoclonal antibodies, preventing typical injuries, implies a central role of the white blood cells in reperfusion injury. Specifically, oxygen free radical formation in the intestines may trigger or cause injury in other distant organs, e.g., the heart and lungs, and affect overall vascular function. So-called "bacterial translocation" from the intestines to the lymphatic vessels and the bloodstream is a more recently discovered phenomenon whose role is largely unknown. Ischemic preconditioning is still another concept, mainly tested in the canine heart, that has potential clinical applications. Reperfusion of ischemic tissue occurs with solid organ transplantation, often after considerable cold ischemia time. Protective mechanisms include oxygen free radical scavengers, i.e., allopurinol and superoxide dismutase. Other measures proven to be effective during the implantation are blood volume expansion with colloid solutions and/or electrolyte solutions, and the administration of a calcium antagonist. The mechanisms of these measures are likely related to improved renal microcirculation and relief of vasospasm. |
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Authors:
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A Ar'Rajab; I Dawidson; R Fabia |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: New horizons (Baltimore, Md.) Volume: 4 ISSN: 1063-7389 ISO Abbreviation: New Horiz Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-11-19 Completed Date: 1996-11-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9416195 Medline TA: New Horiz Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 224-34 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Texas, South-western Medical Center at Dallas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacterial Translocation Calcium / physiology Free Radicals / metabolism Humans Ischemic Preconditioning Leukocytes / physiology Organ Transplantation Reperfusion Injury / physiopathology* Xanthine Oxidase / physiology |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 7440-70-2/Calcium; EC 1.17.3.2/Xanthine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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