| Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses. | |
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MedLine Citation:
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PMID: 20955430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic and intermittent ischemic vascular disorders represent a burgeoning clinical challenge. Previous studies have focused on the idea that therapeutic angiogenesis strategies could alleviate tissue ischemia; however, it is now appreciated that vascular disease is not simply limited to vascular wall cells but also influenced by simultaneously occurring inflammatory responses. Our laboratory has discovered that pharmacological treatment of permanent tissue ischemia with dipyridamole significantly augments ischemic tissue reperfusion, angiogenesis, and arteriogenesis over time. We have found that the beneficial effects of dipyridamole therapy are due to its ability to increase tissue nitric oxide bioavailability that corrects tissue redox imbalance. Importantly, we have also discovered that dipyridamole treatment invoking nitric oxide (NO) production significantly downregulates various innate immune response genes during chronic ischemic tissue injury. These findings demonstrate that dipyridamole-induced production of nitrite/NO significantly decreases inflammatory responses while increasing vascular growth in ischemic tissues. |
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Authors:
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Christopher B Pattillo; Kai Fang; Justin Terracciano; Christopher G Kevil |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1207 ISSN: 1749-6632 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2010-11-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 83-8 Citation Subset: IM |
Copyright Information:
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© 2010 New York Academy of Sciences. |
Affiliation:
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Department of Pathology, LSU Health Sciences Center-Shreveport, Shreveport, Louisiana, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dipyridamole / pharmacology* Down-Regulation / drug effects Humans Immunity, Innate / drug effects*, genetics Inflammation / prevention & control Ischemia / drug therapy*, immunology*, metabolism Neovascularization, Physiologic / drug effects Nitric Oxide / metabolism Nitrites / pharmacology* Reperfusion / methods* |
| Grant Support | |
ID/Acronym/Agency:
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HL 080482/HL/NHLBI NIH HHS; HL 094021/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitrites; 10102-43-9/Nitric Oxide; 58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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