| Reperfusion after a two-hour period of pulmonary artery occlusion causes pulmonary necrosis. | |
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MedLine Citation:
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PMID: 1416395 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of reperfusion injury in the progression to necrosis in pulmonary embolism was evaluated. To simulate this condition, we used a technique that enables occlusion and reopening of the pulmonary arterial branch supplying the right upper lobe in conscious rats. The rats were divided into five groups: the occlusion group (n = 12), in which the pulmonary artery (PA) branch was occluded without reperfusion; the reperfusion group (n = 12), in which the PA branch was reopened after a 2-h period of occlusion; and the reperfusion-SOD (n = 9), reperfusion-IM (n = 8), or reperfusion-IA-SOD (n = 6) groups, in which superoxide dismutase (SOD), indomethacin (IM), or inactivated SOD (IA-SOD), respectively, was administered during reperfusion. The lungs were removed 24 h after the PA occlusion, and histologic examination was performed. In the occlusion group, the alveolar structure of the right upper lobe was well preserved, and there was no erythrocyte or leukocyte accumulation. The only significant changes compared with the control lobe was the appearance of wavy internal elastic lamina of the PA and slight neutrophil adherence to the endothelial cells. In contrast, the right upper lobe of the reperfusion group disclosed numerous foci of hemorrhagic necrosis, with disrupted alveoli and leukocyte accumulation in all cases. With SOD treatment, the changes compatible with hemorrhagic necrosis were attenuated to the level of the control lobes. However, neither IM nor IA-SOD decreased these changes.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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T Murata; H Nakazawa; I Mori; Y Ohta; H Yamabayashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American review of respiratory disease Volume: 146 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1992 Oct |
Date Detail:
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Created Date: 1992-10-30 Completed Date: 1992-10-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1048-53 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, School of Medicine, Tokai University, Kanagawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Constriction Indomethacin / therapeutic use* Lung / pathology* Male Pulmonary Alveoli / pathology Pulmonary Artery* Pulmonary Embolism / pathology* Rats Rats, Wistar Recombinant Proteins / therapeutic use Reperfusion Injury / pathology*, prevention & control Superoxide Dismutase / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 53-86-1/Indomethacin; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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