Document Detail


Repeated stimulation of CRF receptors in the BNST of rats selectively induces social but not panic-like anxiety.
MedLine Citation:
PMID:  18288095     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased extra-hypothalamic corticotrophin-releasing factor (CRF) neurotransmission has been suggested as one putative factor in the pathophysiology of anxiety disorders. We have previously reported that administering repeated subanxiogenic doses (termed 'priming') of the CRF receptor agonist urocortin 1 (Ucn1) into the basolateral amygdala (BLA) of rats elicited long-lasting behavioral changes in social interaction (SI) and elevated plus maze (EPM) tests of anxiety. Although substantial similarity exists, the bed nucleus of the stria terminals (BNST) and the amygdala are thought to play distinct roles in anxiety responses. Rats primed with Ucn1 in the BLA not only demonstrated increased anxiety-like behaviors, but also physiological sensitivity to intravenous sodium lactate infusions, which is seen in subjects with panic or posttraumatic stress disorders, but not social or generalized anxiety disorders. In the present study, we tested if similar priming with subanxiogenic doses of Ucn1 in the BNST of rats will induce either chronic anxiety or sensitivity to sodium lactate. After determining the dose of Ucn1 that is subanxiogenic when injected into the BNST, repeated intra-BNST injections of this subanxiogenic dose of Ucn1 (6 fmol/100 nl) elicited persistent (present even after 4 weeks) anxiety-like responses in the SI but not EPM test. Prior local injection of a CRF receptor antagonist, astressin, into the BNST blocked this effect. Unlike Ucn1 priming in the BLA, rats primed in the BNST showed no cardiovascular changes following lactate infusion. Thus, BNST priming appears to selectively model the pathophysiology of subjects with anxiety syndromes like social anxiety, which are not lactate sensitive.
Authors:
Younglim Lee; Stephanie Fitz; Philip L Johnson; Anantha Shekhar
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-02-20
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  33     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-12     Completed Date:  2009-04-22     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2586-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / chemically induced,  metabolism*,  physiopathology*
Corticotropin-Releasing Hormone / administration & dosage
Male
Panic / drug effects,  physiology*
Peptide Fragments / administration & dosage
Rats
Rats, Wistar
Receptors, Corticotropin-Releasing Hormone / agonists,  antagonists & inhibitors,  physiology*
Septal Nuclei / drug effects,  physiology*
Social Behavior*
Urocortins / administration & dosage
Grant Support
ID/Acronym/Agency:
R01 MH052619/MH/NIMH NIH HHS; R01 MH052619-12/MH/NIMH NIH HHS; R01 MH065702/MH/NIMH NIH HHS; R01 MH52619/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/Receptors, Corticotropin-Releasing Hormone; 0/Urocortins; 170809-51-5/astressin; 9015-71-8/Corticotropin-Releasing Hormone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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