Document Detail

Repeated sauna therapy increases arterial endothelial nitric oxide synthase expression and nitric oxide production in cardiomyopathic hamsters.
MedLine Citation:
PMID:  15914953     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vascular endothelial dysfunction is involved in the pathophysiology of chronic heart failure (CHF). It has been reported that sauna therapy, which allows thermal vasodilation, improves vascular endothelial dysfunction in patients with CHF. The present study investigates the mechanisms through which sauna therapy improves endothelial dysfunction induced by CHF. METHODS AND RESULTS: Normal control and male TO-2 cardiomyopathic hamsters were used. Thirty-week-old TO-2 hamsters were treated daily with an experimental far infrared-ray dry sauna system for 15 min at 39 degrees C followed by 20 min at 30 degrees C. This procedure raised the rectal temperatures by about 1 degrees C. Arterial endothelial nitric oxide (NO) synthase (eNOS) mRNA and protein expressions were examined, and serum concentrations of nitrate were measured. The expression of eNOS mRNA in the aortas of normal controls did not change, whereas those of the TO-2 hamsters decreased with age. Four weeks of sauna therapy significantly increased eNOS mRNA expression in the aortas of TO-2 hamsters compared with those that did not undergo sauna therapy. Sauna therapy also upregulated aortic eNOS protein expression. Serum nitrate concentrations of the TO-2 hamsters were increased by 4 weeks of sauna therapy compared with those that did not undergo sauna. CONCLUSION: Repeated sauna therapy increases eNOS expression and NO production in cardiomyopathic hamsters with heart failure.
Yoshiyuki Ikeda; Sadatoshi Biro; Yasuyuki Kamogawa; Shiro Yoshifuku; Hideyuki Eto; Koji Orihara; Bo Yu; Takashi Kihara; Masaaki Miyata; Shuichi Hamasaki; Yutaka Otsuji; Shinichi Minagoe; Chuwa Tei
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  69     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-25     Completed Date:  2005-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  722-9     Citation Subset:  IM    
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kogoshima, Japan.
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MeSH Terms
Cardiomyopathies / metabolism*,  pathology,  therapy
Gene Expression Regulation, Enzymologic*
Heart Failure / metabolism,  pathology,  therapy
Nitric Oxide / biosynthesis*
Nitric Oxide Synthase / biosynthesis*
Nitric Oxide Synthase Type III
Steam Bath*
Reg. No./Substance:
10102-43-9/Nitric Oxide; EC Oxide Synthase; EC Oxide Synthase Type III

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