| Repeated pre-exposure to morphine into the ventral pallidum enhances morphine-induced place preference: involvement of dopaminergic and opioidergic mechanisms. | |
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MedLine Citation:
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PMID: 17451818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, the effect of repeated administration of morphine into the ventral pallidum (intra-VP) on the conditioned place preference (CPP) induced by systemic morphine injection was investigated in male Wistar rats. Subcutaneous (s.c.) administration of morphine (2.5, 5 and 7.5mg/kg), during conditioning, induced conditioned place preference (CPP). The maximum response was obtained with 5mg/kg of morphine. Lower dose of morphine (0.5mg/kg) did not induce CPP, but in the animals which had previously, received 3 days intra-VP repeated injections of morphine (3 or 5microg/rat) followed by 5 days free of the drug, elicited a significant CPP. Moreover, 3 days intraperitoneal (i.p.) pretreatment with different doses of naloxone (0.5, 1 and 2mg/kg), SCH 23390 (0.012, 0.025 and 0.05mg/kg) or sulpiride (6.2, 12.5 and 25mg/kg) in combination with repeated injections of morphine (5microg/rat), blocked the opioid response on the acquisition of morphine (0.5mg/kg) CPP. On the other hand, our results showed that 3 days single repeated administration of different doses of naloxone (0.5, 1 or 2mg/kg, i.p.), SCH 23390 but not sulpiride followed by 5 days free of the drug, significantly decreased the acquisition of morphine (0.5mg/kg) CPP and also induced place aversion. Furthermore, the drugs' injections had no effect on locomotor activity on the testing phase of CPP. It is concluded that repeated intra-VP injections of morphine induces behavioral sensitization, which may be due to the opioidrgic and/or dopaminergic mechanism(s). |
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Authors:
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Mohammad-Reza Zarrindast; Mohaddeseh Ebrahimi-Ghiri; Parvin Rostami; Ameneh Rezayof |
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Publication Detail:
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Type: Journal Article Date: 2007-03-19 |
Journal Detail:
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Title: Behavioural brain research Volume: 181 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-05-25 Completed Date: 2007-08-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 35-41 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran. zarinmr@ams.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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metabolism* Analysis of Variance Animals Behavior, Animal / drug effects Benzazepines / pharmacology Conditioning, Operant / drug effects* Dopamine / metabolism* Dopamine Antagonists / pharmacology Dose-Response Relationship, Drug Drug Administration Schedule Drug Interactions Globus Pallidus / drug effects* Male Morphine / administration & dosage* Motor Activity / drug effects Naloxone / pharmacology Narcotic Antagonists / pharmacology Narcotics / administration & dosage* Rats Rats, Wistar Sulpiride / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Benzazepines; 0/Dopamine Antagonists; 0/Narcotic Antagonists; 0/Narcotics; 15676-16-1/Sulpiride; 465-65-6/Naloxone; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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