| Repeated physiologic stresses provide persistent cardioprotection against ischemia-reperfusion injury in rats. | |
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MedLine Citation:
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PMID: 12204517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We investigated the time course of myocardial tolerance to ischemia-reperfusion injury after repeated physiologic or pharmacologic stresses. BACKGROUND: Sublethal stress provides cardiac tolerance to ischemia-reperfusion injury and increases the activity of manganese superoxide dismutase (Mn-SOD) in the myocardium in a biphasic manner. However, few studies have investigated the time course of the cardioprotective effects after repeated stresses. METHODS: One or two episodes of the same physiologic or pharmacologic stress (exercise, whole-body hyperthermia, or tumor necrosis factor-alpha treatment), or a combination of two different types of stress, were induced after a 48-h interval. The rats were then subjected to 20 min of left coronary artery occlusion, followed by 48 h of reperfusion. The interval between the last stimulus and the induced ischemia was between 0.5 h and 168 h. The incidence of ventricular fibrillation during ischemia and the size of the myocardial infarct after reperfusion were then examined. RESULTS: When two episodes of physiologic or pharmacologic stress were induced, the beneficial effects against ischemia-reperfusion injury were observed in a monophasic manner. These effects persisted for a period of 0.5 to 60 h. One episode of sublethal stress provoked the same beneficial effects, but in a biphasic manner. The increase in Mn-SOD activity in the cardiac tissue resembled the time course for cardioprotection against ischemia-reperfusion injury. CONCLUSIONS: Two episodes of physiologic or pharmacologic stress can provide persistent cardioprotective effects against ischemia-reperfusion injury. |
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Authors:
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Shiro Hoshida; Nobushige Yamashita; Kinya Otsu; Masatsugu Hori |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 40 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-09-02 Completed Date: 2002-09-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 826-31 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Osaka Rosai Hospital, Sakai, Japan. hoshidas@city.yao.osaka.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hyperthermia, Induced* Male Myocardial Infarction / drug therapy*, physiopathology Myocardial Reperfusion Injury / physiopathology, prevention & control* Physical Conditioning, Animal* Rats Rats, Wistar Tumor Necrosis Factor-alpha / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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