Document Detail


Repeated peripheral airway hyperpnea causes inflammation and remodeling in dogs.
MedLine Citation:
PMID:  12673144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION/PURPOSE: Elite winter athletes have an increased incidence of asthma, the cause of which is unknown. Strenuous exercise, particularly while breathing cold air, results in airway cooling and desiccation. We used a canine model of hyperpnea with cold, dry air to test the hypothesis that repeated cooling and desiccation of peripheral airways can cause asthma-like pathology. METHODS: Canine sublobar airways were challenged with room temperature, dry air insufflated though a bronchoscope to simulate the mucosal cooling and desiccation that occurs in human peripheral airways during strenuous cold weather exercise. Airways were challenged once daily on four consecutive days, and control and challenged airways were harvested 24 h after the last challenge for histological analyses. RESULTS: Repeated challenge caused airway obstruction and remodeling that persisted for at least 24 h. The percentage of mucosal squamous epithelium increased with a corresponding decrease in ciliated epithelium. Challenged airways had thicker lamina propria that contained greater concentrations of eosinophils, neutrophils, and mast cells when compared with control airways. The severity of airway obstruction was correlated with mucosal condition, airway thickness, and eosinophil infiltration. With the exception of mast cell infiltration, all changes were reversed within 1 wk of cessation of challenges. CONCLUSIONS: We conclude that repeated cooling and desiccation of peripheral airways can cause airway remodeling similar to that seen in asthma. These findings, in concert with other reports using this model, support the hypothesis that asthma-like symptoms found in winter athletes may be the result of repeated hyperpnea with cold air.
Authors:
Michael S Davis; Brian Schofield; Arthur N Freed
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  35     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-03     Completed Date:  2004-03-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  608-16     Citation Subset:  IM; S    
Affiliation:
Department of Environmental Health Sciences, School of Public Health, The Johns Hopkins University, Baltimore, MD, USA. msdavis@okstate.edu
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MeSH Terms
Descriptor/Qualifier:
Air
Animals
Asthma, Exercise-Induced / physiopathology*,  veterinary
Cold Temperature*
Disease Models, Animal
Dogs
Humans
Inflammation*
Physical Conditioning, Animal
Respiration
Respiratory System / immunology*,  pathology*
Running
Grant Support
ID/Acronym/Agency:
ES03819/ES/NIEHS NIH HHS; HL07534-14/HL/NHLBI NIH HHS; HL51930/HL/NHLBI NIH HHS; HL63186/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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