Document Detail

Repeated miscarriages in patients with antiphospholipid syndrome and subjected to in vitro fertilization: the importance of preimplantation genetic diagnosis.
MedLine Citation:
PMID:  22635220     Owner:  NLM     Status:  In-Data-Review    
The aim of this study was to investigate two patients with antiphospholipid syndrome (APS) who suffered from multiple repeated pregnancy losses of probably genetically impaired embryos. Sera from these patients contained high levels of IgG antibodies against cardiolipin, IgG and IgM phosphatidyl inositol, IgG phosphatidyl L-serine, and IgG against anti-annexin V. The conventional treatment of APS was ineffective. Preimplantation genetic diagnosis (PGD) showed chromosomally impaired embryos. The course of pregnancies and deliveries were monitored due to the close collaboration of in vitro fertilization and PGD in early embryos. After the selection of normal embryos using PGD, and the treatment of APS, both patients became pregnant and delivered healthy babies. Without such selection, both women would probably have miscarried their embryos again.
Z Ulcova-Gallova
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lupus     Volume:  21     ISSN:  1477-0962     ISO Abbreviation:  Lupus     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  England    
Other Details:
Languages:  eng     Pagination:  744-6     Citation Subset:  IM    
Department of Gynecology and Obstetrics, School of Medicine, Charles University and University Hospital, Pilsen, Czech Republic.
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