Document Detail

Repeated measurement of spontaneous and clastogen-induced sister-chromatid exchange.
MedLine Citation:
PMID:  1691444     Owner:  NLM     Status:  MEDLINE    
Sister-chromatid exchanges (SCE), both spontaneous and chemically-induced [bleomycin (BLM), mitomycin-C (MMC), streptonigrin (SN), and 4-nitroquinoline-1-oxide (4NQO)], were studied in the lymphocytes of 24 normal individuals on 2 or 3 different occasions, separated by periods of up to 2 years. For all BLM-induced SCEs, the variation in SCE frequency among the samples from a single individual was significantly greater than the variation between replicate cultures on a given day. These results raise questions concerning the validity of conclusions based on a single observation of chemically-induced SCEs.
S Schwartz; J A Astemborski; A P Budacz; J A Boughman; S S Wasserman; M M Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  234     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-15     Completed Date:  1990-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  51-9     Citation Subset:  IM    
Department of Obstetrics/Gynecology, University of Maryland School of Medicine, Baltimore 21201.
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MeSH Terms
4-Nitroquinoline-1-oxide / pharmacology
Bleomycin / pharmacology
Lymphocytes / cytology,  drug effects
Mitomycins / pharmacology
Mutagens / pharmacology*
Reference Values
Sister Chromatid Exchange* / drug effects
Streptonigrin / pharmacology
Reg. No./Substance:
0/Mitomycins; 0/Mutagens; 11056-06-7/Bleomycin; 3930-19-6/Streptonigrin; 50-07-7/Mitomycin; 56-57-5/4-Nitroquinoline-1-oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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