Document Detail

Repeated low-dose computed tomography in current and former smokers for quantification of emphysema.
MedLine Citation:
PMID:  21084912     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To quantify different emphysema evolution in current and former smokers.
METHODS: We retrospectively analyzed low-dose computed tomography scans from a lung cancer screening study of 59 current and 75 former smokers. The quantitative emphysema analysis was performed using a home-built software (YACTA version 0.9), yielding the parameters lung volume, emphysema volume (EV), emphysema index (EI), mean lung density, and 15th percentile.
RESULTS: The baseline EV and EI were significantly different (median EVformer =422 mL vs EVcurrent =249 mL, P = 0.0003; and median EIformer =7.6 % vs EIcurrent =4.1 %, P = 0.0001, respectively). On the annual repeat scan, the median EI and EV for former smokers had decreased significantly (ΔEIformer = -0.257%, P = 0.004; and ΔEVcurrent = -0.203 mL, P = 0.020), whereas there was no emphysema change in current smokers.
CONCLUSIONS: We were able to demonstrate different emphysema evolution in current versus former smokers; emphysema parameters decreased in the former smokers and remained stable in current smokers.
Alexander McGregor; Heidi C Roberts; Zhi Dong; Ravi Menezes; Hans-Ulrich Kauczor; Oliver Weinheimer; Claus Peter Heussel
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of computer assisted tomography     Volume:  34     ISSN:  1532-3145     ISO Abbreviation:  J Comput Assist Tomogr     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-18     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703942     Medline TA:  J Comput Assist Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  933-8     Citation Subset:  IM    
Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.
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MeSH Terms
Middle Aged
Pulmonary Emphysema / pathology,  radiography*
Radiation Dosage
Retrospective Studies
Statistics, Nonparametric
Tomography, X-Ray Computed / methods*

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