| Repeated low-dose computed tomography in current and former smokers for quantification of emphysema. | |
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MedLine Citation:
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PMID: 21084912 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To quantify different emphysema evolution in current and former smokers. METHODS: We retrospectively analyzed low-dose computed tomography scans from a lung cancer screening study of 59 current and 75 former smokers. The quantitative emphysema analysis was performed using a home-built software (YACTA version 0.9), yielding the parameters lung volume, emphysema volume (EV), emphysema index (EI), mean lung density, and 15th percentile. RESULTS: The baseline EV and EI were significantly different (median EVformer =422 mL vs EVcurrent =249 mL, P = 0.0003; and median EIformer =7.6 % vs EIcurrent =4.1 %, P = 0.0001, respectively). On the annual repeat scan, the median EI and EV for former smokers had decreased significantly (ΔEIformer = -0.257%, P = 0.004; and ΔEVcurrent = -0.203 mL, P = 0.020), whereas there was no emphysema change in current smokers. CONCLUSIONS: We were able to demonstrate different emphysema evolution in current versus former smokers; emphysema parameters decreased in the former smokers and remained stable in current smokers. |
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Authors:
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Alexander McGregor; Heidi C Roberts; Zhi Dong; Ravi Menezes; Hans-Ulrich Kauczor; Oliver Weinheimer; Claus Peter Heussel |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 34 ISSN: 1532-3145 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: United States |
Other Details:
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Languages: eng Pagination: 933-8 Citation Subset: IM |
Affiliation:
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Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Male Middle Aged Pulmonary Emphysema / pathology, radiography* Radiation Dosage Retrospective Studies Smoking* Software Statistics, Nonparametric Tomography, X-Ray Computed / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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