Document Detail


Repeated long separations from pups produce depression-like behavior in rat mothers.
MedLine Citation:
PMID:  17118566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long maternal (LMS) versus brief maternal (BMS) daily separations of rat pups from their mothers have contrasting effects on their adult stress responses and maternal behavior by, respectively, decreasing and increasing licking received from their mothers. We hypothesized that LMS decreases pup-licking in mothers by inducing learned helplessness, creating a depression-like state. We subjected postpartum rats to LMS (3 h), BMS (15 min) or no separation (NMS) on postpartum days 2-14. After weaning, mothers were given a forced swim test (FST). LMS mothers exhibited more immobility and fewer escape attempts than BMS or NMS mothers. These results suggest that LMS induces a depression-like state, which may account for the reductions in maternal behavior seen in LMS mothers. Immobility in the FST is recognized as an animal model of depression. Therefore, LMS may be a model of maternal depression.
Authors:
Maria L Boccia; Maria Razzoli; Sivaram Prasad Vadlamudi; Whit Trumbull; Christopher Caleffie; Cort A Pedersen
Related Documents :
23254446 - Resonance raman spectroscopy and the preterm infant carotenoid status.
2519606 - Entrainment of the melatonin rhythms in early postnatal lambs and their mothers.
17050296 - Mother's early perception of her infant's difficult temperament, parenting stress and e...
17895226 - Producing sons reduces lifetime reproductive success of subsequent offspring in pre-ind...
15480376 - Gastric emptying in very-low-birth-weight infants treated with nasal continuous positiv...
18366486 - Current caesarean delivery rates and indications in a major public hospital in northern...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-11-22
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  32     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-04-06     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  65-71     Citation Subset:  IM    
Affiliation:
FPG Child Development Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-8185, USA. Maria_Boccia@unc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Behavior, Animal
Depression / etiology*
Female
Helplessness, Learned
Male
Maternal Behavior*
Maternal Deprivation*
Motor Activity
Postpartum Period / psychology
Pregnancy
Rats
Rats, Long-Evans
Swimming
Grant Support
ID/Acronym/Agency:
MH066217/MH/NIMH NIH HHS; MH61995/MH/NIMH NIH HHS; R01 MH061995-04/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hemispheric differences in protein kinase C betaII levels in the rat amygdala: baseline asymmetry an...
Next Document:  Towards a better understanding of the aetiology of Legg-Calvé-Perthes' disease: acetabular retrover...