| Repeated increases in blood flow, independent of exercise, enhance conduit artery vasodilator function in humans. | |
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MedLine Citation:
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PMID: 21131471 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study aimed to determine the importance of repeated increases in blood flow to conduit artery adaptation, using an exercise-independent repeated episodic stimulus. Recent studies suggest that exercise training improves vasodilator function of conduit arteries via shear stress-mediated mechanisms. However, exercise is a complex stimulus that may induce shear-independent adaptations. Nine healthy men immersed their forearms in water at 42°C for three 30-min sessions/wk across 8 wk. During each session, a pneumatic pressure cuff was inflated around one forearm to unilaterally modulate heating-induced increases in shear. Forearm heating was associated with an increase in brachial artery blood flow (P < 0.001) and shear rate (P < 0.001) in the uncuffed forearm; this response was attenuated in the cuffed limb (P < 0.005). Repeated episodic exposure to bilateral heating induced an increase in endothelium-dependent vasodilation in response to 5-min ischemic (P < 0.05) and ischemic handgrip exercise (P < 0.005) stimuli in the uncuffed forearm, whereas the 8-wk heating intervention did not influence dilation to either stimulus in the cuffed limb. Endothelium-independent glyceryl trinitrate responses were not altered in either limb. Repeated heating increases blood flow to levels that enhance endothelium-mediated vasodilator function in humans. These findings reinforce the importance of the direct impacts of shear stress on the vascular endothelium in humans. |
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Authors:
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Louise H Naylor; Howard Carter; Matthew G Fitzsimons; N Timothy Cable; Dick H J Thijssen; Daniel J Green |
Publication Detail:
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Type: Journal Article Date: 2010-12-03 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 300 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H664-9 Citation Subset: IM |
Affiliation:
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School of Sports Science, Exercise and Health, The Univ. of Western Australia M408, Crawley, 6009 Western Australia. brevis@cyllene.uwa.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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