Document Detail


Repeated fluorodeoxyglucose positron emission tomography of the brain in infants with suspected hypoxic-ischaemic brain injury.
MedLine Citation:
PMID:  8223769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Positron emission tomography (PET) permits the study of cerebral metabolism in vivo. We performed repeated PET studies with fluorine-18 fluorodeoxyglucose (FDG) as a tracer to measure cerebral glucose metabolism for estimation of neurological prognosis in infants with suspected hypoxic-ischaemic brain injury. Fourteen infants (gestational age 35.3 +/- 4.67 weeks) were examined during the neonatal period (at age 38.4 +/- 2.7 weeks) and again at the age of 3.5 +/- 0.7 months; one further infant was studied only once at the age of 2.5 months. All children also underwent ultrasound examinations. Electroencephalography and computed tomography or magnetic resonance imaging were performed according to their clinical condition and their neurological development has been followed. FDG accumulated most actively in the subcortical areas (thalami, brainstem and cerebellum) and the sensorimotor cortex during the neonatal period. The repeated PET study showed that the uptake of FDG was markedly high and increased in all brain sections of infants with normal development (n = 11), whereas those with delayed development (n = 4) had significantly lower values (P < or = 0.005).
Authors:
H Suhonen-Polvi; P Kero; H Korvenranta; U Ruotsalainen; M Haaparanta; J Bergman; O Simell; U Wegelius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  20     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-16     Completed Date:  1993-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  759-65     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Turku University Central Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Brain Ischemia / radionuclide imaging*
Deoxyglucose / analogs & derivatives,  diagnostic use
Fluorodeoxyglucose F18
Humans
Hypoxia, Brain / radionuclide imaging*
Infant, Newborn
Infant, Newborn, Diseases / radionuclide imaging*
Infant, Premature, Diseases / radionuclide imaging*
Tomography, Emission-Computed*
Chemical
Reg. No./Substance:
154-17-6/Deoxyglucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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