Document Detail

Repeated exposures to hyperbaric air suppress neurite outgrowth in PC12 cells.
MedLine Citation:
PMID:  17971265     Owner:  NLM     Status:  MEDLINE    
Hyperbaric exposure induces lesions of the CNS in scuba divers. Repeated exposures to hyperbaric air at 0.5 MPa for 30 min with short intervals suppressed NGF-stimulated neurite outgrowth, concomitant with a decrease in the protein expression of ERK in PC12 cells. Hyperbaric exposure most likely causes direct lesions of neural cells.
Tetsuro Isada; Munetaka Hirose; Eri Murata; Yoko Okayama; Mayumi Takatori; Mayumi Tani; Keita Fukazawa; Masashi Hirata; Satoshi Taniguchi; Kenji Shigemi; Yoshifumi Tanaka
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Publication Detail:
Type:  Journal Article     Date:  2007-11-01
Journal Detail:
Title:  The journal of physiological sciences : JPS     Volume:  57     ISSN:  1880-6546     ISO Abbreviation:  J Physiol Sci     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-26     Completed Date:  2008-08-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101262417     Medline TA:  J Physiol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  321-5     Citation Subset:  IM    
Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, Fukui University, Eiheijicho, Yoshidagun, Fukui, 910-1193, Japan.
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MeSH Terms
Air Pressure*
Cell Differentiation / physiology*
Extracellular Signal-Regulated MAP Kinases / analysis,  metabolism
Nerve Growth Factor / pharmacology
Neurites / drug effects,  physiology*
PC12 Cells
Receptor, trkA / metabolism
Reg. No./Substance:
9061-61-4/Nerve Growth Factor; EC, trkA; EC Signal-Regulated MAP Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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