Document Detail

Repeated exposure to low-dose diesel exhaust after allergen challenge exaggerates asthmatic responses in mice.
MedLine Citation:
PMID:  16979384     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In conjunction with allergens, diesel exhaust particles act as an adjuvant to enhance IgE responses, inducing expression of cytokines/chemokines and adhesion molecules, and increasing airway hyper-responsiveness (AHR). As most studies were designed to expose animals to diesel exhaust throughout the periods of both sensitization and allergen challenge, it remains unclear whether diesel exhaust (DE) exposure exaggerates airway responses in asthmatic animals. OBJECTIVE: To study effects of exposure to low-dose DE on AHR and allergic airway inflammation in asthmatic mice. METHODS: BALB/c mice were sensitized by intraperitoneal injection of ovalbumin and challenged by intranasal administration with ovalbumin. They were exposed to low-dose DE for 7 h/day, 5 days/week, for up to 12 weeks. AHR to methacholine was evaluated by whole-body plethysmography as well as bronchoalveolar lavage cell analysis and cytokine gene expression in lungs. RESULTS: Repeated exposure of asthmatic mice to low-dose DE resulted in increased AHR and gene expression of several pro-asthmatic cytokines/chemokines, but these effects rapidly subsided with continued exposure to DE. CONCLUSION: Repeated exposure to low-dose DE after ovalbumin challenge exaggerates allergic responses in mice, but effects are not prolonged with continuous DE exposure.
Aki Matsumoto; Kumiko Hiramatsu; Yingji Li; Arata Azuma; Shoji Kudoh; Hajime Takizawa; Isamu Sugawara
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Publication Detail:
Type:  Journal Article     Date:  2006-09-18
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  121     ISSN:  1521-6616     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2006-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-35     Citation Subset:  IM    
Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Allergens / immunology*
Asthma / chemically induced,  immunology,  physiopathology*
Bronchial Hyperreactivity / etiology,  immunology*
Bronchoalveolar Lavage Fluid / cytology
Chemokines / metabolism
Cytokines / metabolism
Disease Models, Animal
Inhalation Exposure*
Lung / ultrastructure
Mice, Inbred BALB C
RNA, Messenger / metabolism*
Vehicle Emissions / toxicity*
Reg. No./Substance:
0/Allergens; 0/Chemokines; 0/Cytokines; 0/RNA, Messenger; 0/Vehicle Emissions; 9006-59-1/Ovalbumin

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