Document Detail


Repeated endothelial removal augments intimal thickening and attenuates EDRF release.
MedLine Citation:
PMID:  7514359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the significance of repeated denudation injury in progression of atherosclerosis, we performed a single and then a second balloon denudation on the rabbit carotid arteries. Morphological examinations and organ chamber experiments were performed, and the results were compared. On morphological examinations, reendothelialization was almost completed in 2 wk after redenudation, whereas it required 6 wk after a single denudation. Intimal thickening progressed after redenudation. Organ chamber experiments showed that contractile responses and endothelium-independent relaxation remained unchanged after redenudation. Endothelium-dependent relaxations to acetylcholine, ADP, and substance P decreased progressively by repeating denudation. These relaxation responses were inhibited by NG-nitro-L-arginine, hemoglobin, and methylene blue and were considered to be associated with the production and/or release of endothelium-derived relaxing factor-nitric oxide (EDRF-NO). The diffusion barrier mechanism for the decreased endothelium-dependent relaxations was ruled out using sandwich experiments. In conclusion, repeated endothelial denudation caused progression of intimal thickening and acceleration of endothelial regeneration, and repeated endothelial regeneration resulted in progressively less production and/or release of EDRF-NO.
Authors:
Y Niimi; H Azuma; K Hirakawa
Related Documents :
19411289 - Limits of isolation and culture: intact vascular endothelium and bkca.
16490839 - Endothelium-derived epoxyeicosatrienoic acids and vascular function.
2872069 - Alpha 1- and alpha 2-adrenoceptor agonist-induced contraction in rat mesenteric artery ...
17926269 - Endothelial no/cgmp-dependent vascular relaxation of cornuside isolated from the fruit ...
12631359 - Vitamin c improves resistance but not conduit artery endothelial function in patients w...
12381679 - The impairment of endothelium-dependent arterial relaxation by 7-ketocholesterol is ass...
21853419 - Improved in vitro cultivation of endothelial progenitor cells as basis for dermal subst...
21349159 - Notch modulates vegf action in endothelial cells by inducing matrix metalloprotease act...
17967169 - The adhesion molecule necl-3/syncam-2 localizes to myelinated axons, binds to oligodend...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  266     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-06-10     Completed Date:  1994-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1348-56     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Tokyo Medical and Dental University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Adenosine Diphosphate / pharmacology
Animals
Carotid Arteries / cytology,  drug effects,  physiology
Endothelium, Vascular / cytology,  metabolism*,  physiology*
Male
Microscopy, Electron, Scanning
Nitric Oxide / metabolism*
Rabbits
Substance P / pharmacology
Tunica Intima / physiology*
Vasodilation
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 33507-63-0/Substance P; 51-84-3/Acetylcholine; 58-64-0/Adenosine Diphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  P-selectin and ICAM-1-dependent adherence reactions: role in the genesis of postischemic no-reflow.
Next Document:  Modulation of autonomic responses in normal and denervated isolated canine atria by substance P.