Document Detail

Repeated electroconvulsive shock prevents increased neocortical beta 1-adrenoceptor binding after DSP-4 treatment in rats.
MedLine Citation:
PMID:  3032658     Owner:  NLM     Status:  MEDLINE    
Repeated electroconvulsive shock (ECS) was administered to rats previously injected with DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride), a noradrenergic neurotoxin. The normal increase in neocortical beta 1-adrenoceptor binding caused by noradrenaline depletion was effectively prevented by ECS. This finding suggests that the plasticity of the beta 1-adrenoceptor may be partially independent of endogenous noradrenaline concentration. Additionally, functional noradrenergic neurons are not necessarily a critical requirement for the antidepressant effect of electroconvulsive treatment in humans.
D J Dooley; D J Heal; G M Goodwin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  134     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-05-28     Completed Date:  1987-05-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  333-7     Citation Subset:  IM    
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MeSH Terms
Benzylamines / pharmacology*
Cerebral Cortex / drug effects,  metabolism*
Dihydroalprenolol / diagnostic use
Neurotoxins / pharmacology*
Receptors, Adrenergic, beta / drug effects,  metabolism*
Reg. No./Substance:
0/Benzylamines; 0/Neurotoxins; 0/Receptors, Adrenergic, beta; 60106-89-0/Dihydroalprenolol; 62078-98-2/DSP 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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