| Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multicenter study. | |
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MedLine Citation:
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PMID: 21254083 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Granulocyte colony-stimulating factor (G-CSF) induces a transient mobilization of hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was to evaluate safety of repeated courses of G-CSF in patients with amyotrophic lateral sclerosis (ALS), assessing disease progression and changes in chemokine and cytokine levels in serum and cerebrospinal fluid (CSF). Twenty-four ALS patients entered an open-label, multicenter trial in which four courses of G-CSF and mannitol were administered at 3-month intervals. Levels of G-CSF were increased after treatment in the serum and CSF. Few and transitory adverse events were observed. No significant reduction of the mean monthly decrease in ALSFRS-R score and forced vital capacity was observed. A significant reduction in CSF levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-17 (IL-17) was observed. G-CSF treatment was safe and feasible in a multicenter series of ALS patients. A decrease in the CSF levels of proinflammatory cytokines MCP-1 and IL-17 was found, indicating a G-CSF-induced central anti-inflammatory response. |
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Authors:
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Adriano Chiò; Gabriele Mora; Vincenzo La Bella; Claudia Caponnetto; Gianluigi Mancardi; Mario Sabatelli; Gabriele Siciliano; Vincenzo Silani; Massimo Corbo; Cristina Moglia; Andrea Calvo; Roberto Mutani; Sergio Rutella; Francesca Gualandi; Mario Melazzini; Rosanna Scimè; Mario Petrini; Paola Bondesan; Silvia Garbelli; Stefania Mantovani; Caterina Bendotti; Corrado Tarella; |
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Publication Detail:
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Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Muscle & nerve Volume: 43 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: 2011-02-24 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 189-95 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Dipartimento di Neuroscienze, Centro per la Sclerosi Laterale Amiotrofica, Torino, Italy. achio@usa.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amyotrophic Lateral Sclerosis / blood, cerebrospinal fluid, drug therapy* Cytokines / blood, cerebrospinal fluid Disability Evaluation Female Follow-Up Studies Granulocyte Colony-Stimulating Factor / blood, cerebrospinal fluid, therapeutic use* Humans Male Middle Aged Pilot Projects Prospective Studies Questionnaires Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 143011-72-7/Granulocyte Colony-Stimulating Factor |
| Investigator | |
Investigator/Affiliation:
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Paolo Ghiglione / ; Paola Omede / ; Marco Ulla / ; Maria Mascolo / ; Cecilia Carlesi / ; Pietro Attilio Tonali / ; Amelia Conte / ; Marco Luigetti / ; Dario Alimonti / ; Francesco Onida / ; Patrizia Bossolasco / ; Giorgio Lambertenghi Deliliers / ; Francesca Valentino / |
| Comments/Corrections | |
Comment In:
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Muscle Nerve. 2011 Jul;44(1):149; author reply 149-50
[PMID:
21674531
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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