Document Detail

Repeated breathlessness experiences induced by hypercapnia: differential effects on intensity and unpleasantness.
MedLine Citation:
PMID:  19201712     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The present study investigated the effect of repeated hypercapnic challenges on the sensory (intensity [I]) and affective (unpleasantness [U]) dimensions of breathlessness. METHODS: Three subsequent rebreathing trials (Read, 1968) were administered to healthy men and women (n = 39). The I and U of breathlessness were rated every 20 s during the baseline, rebreathing, and recovery phases. Breathing behavior (fractional end-tidal CO(2) [Fetco(2)] and minute ventilation [Ve]) was monitored continuously. Intraindividual linear regression slopes for Fetco(2) and Ve] were calculated and standardized, separately for both rating dimensions. RESULTS: Both the absolute magnitude and the slope of the I of breathlessness were higher compared to U (p < 0.05). Across-trial habituation of the peak I and U of breathlessness occurred in both genders (p < 0.001), but habituation was larger for the U than for the I (p = 0.05). CONCLUSIONS: The findings show that the sensory and affective dimensions of breathlessness can meaningfully be distinguished during hypercapnic challenges and that repeated exposures have different effects on both dimensions.
Li Wan; Ilse Van Diest; Steven De Peuter; Katleen Bogaerts; Omer Van den Bergh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  135     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-61     Citation Subset:  AIM; IM    
Department of Psychology, University of Leuven, Leuven, Belgium.
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MeSH Terms
Blood Gas Analysis
Carbon Dioxide / blood*
Dyspnea / etiology,  physiopathology*
Hypercapnia / complications,  physiopathology,  psychology*
Illness Behavior
Inhalation / physiology
Reference Values
Risk Assessment
Sampling Studies
Sensitivity and Specificity
Sensory Thresholds
Sex Factors
Young Adult
Reg. No./Substance:
124-38-9/Carbon Dioxide

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