| Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma model. | |
| | |
MedLine Citation:
|
PMID: 19781626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have reported previously that moderate intensity aerobic exercise training attenuates airway inflammation in a murine asthma model. Recent studies implicate regulatory T (Treg) cells in decreasing asthma-related airway inflammation; as such, the current study examined the effect of exercise on Treg cell function in a murine asthma model. Mice were sensitized with ovalbumin (OVA) prior to the start of exercise training at a moderate intensity 3x/week for 4weeks; exercise was performed as treadmill running (13.5m/min, 0% grade). Mice were OVA challenged repeatedly throughout the exercise protocol. At protocol completion, mice were analyzed for changes in the number and suppressive function of CD4(+)CD25(+)Foxp3(+) cells isolated from lungs, mediastinal lymph nodes, and spleens. Results show that exercise increased significantly the number of Foxp3(+) cells within the lungs and mediastinal lymph nodes, but not the spleens, of OVA-treated mice as compared with sedentary controls. Exercise also enhanced the suppression function of CD4(+)CD25(+)Foxp3(+) Treg cells derived from OVA-treated mice as compared with sedentary controls. Specifically, Treg cells from exercised, OVA-treated mice more effectively suppressed CD4(+)CD25(-) cell proliferation and Th2 cytokine production in vitro. Enhanced suppression was associated with increased protein levels of TGF-beta and lesser amounts of IL-10 and IL-17; however, blocking TGF-beta had no effect on suppressive functions. These data demonstrate that exercise-mediated increases in Treg cell function may play a role in the attenuation of airway inflammation. Further, these results indicate that moderate intensity aerobic exercise training may alter the Treg cell function within the asthmatic airway. |
| | |
Authors:
|
Thomas Lowder; Kari Dugger; Jessy Deshane; Kim Estell; Lisa M Schwiebert |
Related Documents
:
|
18784336 - Exercise promotes alpha7 integrin gene transcription and protection of skeletal muscle. 19020416 - Differential response to a selective cannabinoid receptor antagonist (sr141716: rimonab... 19948976 - Physical exercise prevents cellular senescence in circulating leukocytes and in the ves... 10968646 - Experimental study on the low-intensity millimeter-wave electro-magnetic stimulation of... 12595296 - Inferior vena caval hemodynamics quantified in vivo at rest and during cycling exercise... 15575956 - Value of supplemental interventions to enhance the effectiveness of physical exercise d... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-09-23 |
Journal Detail:
|
Title: Brain, behavior, and immunity Volume: 24 ISSN: 1090-2139 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-11-30 Completed Date: 2010-02-17 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
|
Languages: eng Pagination: 153-9 Citation Subset: IM |
Affiliation:
|
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294-0005, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aerobiosis
/
physiology* Animals Antigens, CD4 / biosynthesis Asthma / immunology*, metabolism Bronchoalveolar Lavage Fluid / cytology Cell Count Female Flow Cytometry Forkhead Transcription Factors / biosynthesis Interleukin-10 / biosynthesis Interleukin-17 / biosynthesis Interleukin-2 Receptor alpha Subunit / biosynthesis Lung / metabolism Lymph Nodes / metabolism Mice Mice, Inbred BALB C Ovalbumin / immunology Physical Conditioning, Animal / physiology* T-Lymphocytes, Regulatory / immunology*, metabolism Transforming Growth Factor beta / biosynthesis |
| Grant Support | |
ID/Acronym/Agency:
|
1F32HL092726/HL/NHLBI NIH HHS; 1R01HL075465/HL/NHLBI NIH HHS; 5T 32HL007553-25/HL/NHLBI NIH HHS; F32 HL092726-02/HL/NHLBI NIH HHS; R01 HL075465-04/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD4; 0/Forkhead Transcription Factors; 0/Foxp3 protein, mouse; 0/Interleukin-17; 0/Interleukin-2 Receptor alpha Subunit; 0/Transforming Growth Factor beta; 130068-27-8/Interleukin-10; 9006-59-1/Ovalbumin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanism of potentiation of endosulfan cytotoxicity by thiram in Ehrlich ascites tumor cells.
Next Document: Loop mediated isothermal amplification combined with nucleic acid lateral flow strip for diagnosis o...