| Repeated binge access to a palatable food alters feeding behavior, hormone profile, and hindbrain c-Fos responses to a test meal in adult male rats. | |
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MedLine Citation:
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PMID: 19535681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Repetitive cycles of palatable food access and chronic calorie restriction alter feeding behaviors and forebrain neural systems. The purpose of this study was to determine the behavioral, endocrine, and meal-related hindbrain neural activation in adult male Sprague-Dawley rats exposed to a binge-access feeding schedule. The binge-access schedule consisted of repeated twice-per-week episodes of acute calorie restriction (to one-third of the previous day's intake) followed by 2 h of concurrent access to high-calorie palatable food (sweetened fat: 90% vegetable shortening-10% sucrose) and chow. The binge-access rats consumed more calories during the "binge" period than rats with continuous access to sweetened fat (continuous-access group) or subjected to repeated acute calorie restriction only (chow-restricted group). The binge-access group also exhibited a approximately 25% increase in sweetened fat intake from week 1 to week 6. Persistence of the binge phenotype in the binge-access animals was demonstrated 2 wk, but not 4 wk, after ad libitum chow. The binge-access and chow-restricted groups maintained a similar normal body composition and hormonal profiles, whereas the continuous-access animals developed an obese phenotype. Terminal ghrelin levels were significantly higher in the binge-access group than in the continuous-access group. Consumption of a standardized meal resulted in more c-Fos-positive cells along the anterior-posterior nucleus of the solitary tract regions in the binge-access group than in naive controls. These results suggest that repeated cycles of acute calorie restriction followed by palatable food produce physiological alterations that may facilitate overconsumption of a highly palatable food during limited-access periods. |
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Authors:
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Nicholas T Bello; Angela S Guarda; Chantelle E Terrillion; Graham W Redgrave; Janelle W Coughlin; Timothy H Moran |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-06-17 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 297 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-25 Completed Date: 2009-09-10 Revised Date: 2010-09-02 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R622-31 Citation Subset: IM |
Affiliation:
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Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins Univ. School of Medicine, Ross 618, 720 Rutland Ave., Baltimore, MD 21205, USA. ntbello@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Animals Body Weight Bulimia / metabolism*, psychology Caloric Restriction Dietary Fats / administration & dosage Dietary Sucrose / administration & dosage Disease Models, Animal Energy Intake Feeding Behavior* Food Preferences* Ghrelin / metabolism Hormones / metabolism* Male Obesity / metabolism, psychology Phenotype Proto-Oncogene Proteins c-fos / metabolism* Rats Rats, Sprague-Dawley Rhombencephalon / metabolism* Solitary Nucleus / metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DK-078484/DK/NIDDK NIH HHS; DK-19302/DK/NIDDK NIH HHS; MH-015330/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Dietary Sucrose; 0/Ghrelin; 0/Hormones; 0/Proto-Oncogene Proteins c-fos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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