Document Detail


Repeated binge access to a palatable food alters feeding behavior, hormone profile, and hindbrain c-Fos responses to a test meal in adult male rats.
MedLine Citation:
PMID:  19535681     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Repetitive cycles of palatable food access and chronic calorie restriction alter feeding behaviors and forebrain neural systems. The purpose of this study was to determine the behavioral, endocrine, and meal-related hindbrain neural activation in adult male Sprague-Dawley rats exposed to a binge-access feeding schedule. The binge-access schedule consisted of repeated twice-per-week episodes of acute calorie restriction (to one-third of the previous day's intake) followed by 2 h of concurrent access to high-calorie palatable food (sweetened fat: 90% vegetable shortening-10% sucrose) and chow. The binge-access rats consumed more calories during the "binge" period than rats with continuous access to sweetened fat (continuous-access group) or subjected to repeated acute calorie restriction only (chow-restricted group). The binge-access group also exhibited a approximately 25% increase in sweetened fat intake from week 1 to week 6. Persistence of the binge phenotype in the binge-access animals was demonstrated 2 wk, but not 4 wk, after ad libitum chow. The binge-access and chow-restricted groups maintained a similar normal body composition and hormonal profiles, whereas the continuous-access animals developed an obese phenotype. Terminal ghrelin levels were significantly higher in the binge-access group than in the continuous-access group. Consumption of a standardized meal resulted in more c-Fos-positive cells along the anterior-posterior nucleus of the solitary tract regions in the binge-access group than in naive controls. These results suggest that repeated cycles of acute calorie restriction followed by palatable food produce physiological alterations that may facilitate overconsumption of a highly palatable food during limited-access periods.
Authors:
Nicholas T Bello; Angela S Guarda; Chantelle E Terrillion; Graham W Redgrave; Janelle W Coughlin; Timothy H Moran
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-06-17
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  297     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-09-10     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R622-31     Citation Subset:  IM    
Affiliation:
Dept. of Psychiatry and Behavioral Sciences, Johns Hopkins Univ. School of Medicine, Ross 618, 720 Rutland Ave., Baltimore, MD 21205, USA. ntbello@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Animals
Body Weight
Bulimia / metabolism*,  psychology
Caloric Restriction
Dietary Fats / administration & dosage
Dietary Sucrose / administration & dosage
Disease Models, Animal
Energy Intake
Feeding Behavior*
Food Preferences*
Ghrelin / metabolism
Hormones / metabolism*
Male
Obesity / metabolism,  psychology
Phenotype
Proto-Oncogene Proteins c-fos / metabolism*
Rats
Rats, Sprague-Dawley
Rhombencephalon / metabolism*
Solitary Nucleus / metabolism
Time Factors
Grant Support
ID/Acronym/Agency:
DK-078484/DK/NIDDK NIH HHS; DK-19302/DK/NIDDK NIH HHS; MH-015330/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Sucrose; 0/Ghrelin; 0/Hormones; 0/Proto-Oncogene Proteins c-fos
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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