Document Detail

Repeated balloon inflations do not diminish ST segment elevation even though coronary collateral recruitment is promoted in pigs.
MedLine Citation:
PMID:  17299262     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Attempts to demonstrate preconditioning during repeated angioplasty balloon inflations (BIs) have not been universally successful. The main obstacle is that the first BI is unreliable, due to the variable degrees of occlusion by the deflated balloon. In the present study, we examined whether ST segment elevation decreases and evaluated its relation to collateral recruitment during repeated angioplasty BIs in the pig. METHODS AND RESULTS: Twenty male pigs, 7 months old, under general anesthesia, underwent 3 repeated BIs of 120 s, with a 5-min interval between them, in the left anterior descending artery or the right coronary artery. A pressure wave wire was used for the measurement of coronary wedge pressure and to obtain the intracoronary ST segment elevation. Intracoronary ST segment elevation was 1.97 +/- 0.76 mV during the 1st BI, 2.09 +/- 0.82 mV during the 2nd BI and 1.84 +/- 0.82 mV during the 3rd BI (p = n.s.). Coronary wedge pressure was 12 +/- 6, 18 +/- 18 and 20 +/- 20 mm Hg (p < 0.05 vs. 1st BI) during the 3 BIs, respectively. CONCLUSION: Repeated BIs do not diminish ST segment elevation in the pig model, even though coronary collateral recruitment is promoted.
Theodore Lyras; Apostolos Papalois; Lykourgos Klamargias; Stamatis Kyrzopoulos; Paraskevi Dafnomili; Zenon S Kyriakides
Publication Detail:
Type:  Journal Article     Date:  2007-02-13
Journal Detail:
Title:  Cardiology     Volume:  108     ISSN:  1421-9751     ISO Abbreviation:  Cardiology     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  340-4     Citation Subset:  IM    
Copyright Information:
(c) 2007 S. Karger AG, Basel.
Second Department of Cardiology, Hellenic Red Cross Hospital, Athens, Greece.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Collateral Circulation*
Coronary Circulation*
Disease Models, Animal
Ischemic Preconditioning, Myocardial / methods*

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