Document Detail

Repeated autologous bone marrow mononuclear cell therapy in patients with large myocardial infarction.
MedLine Citation:
PMID:  19420003     Owner:  NLM     Status:  MEDLINE    
AIMS: We sought to determine whether repeat administration of bone marrow mononuclear cells (BMC) can improve left ventricular function compared with a single infusion in patients with large acute myocardial infarction (AMI).
METHODS AND RESULTS: Thirty-nine patients with a ST-elevation AMI of the anterior wall and a significantly decreased left ventricular ejection fraction (LVEF 20-39%) were randomly assigned to three groups following primary percutaneous coronary intervention: Group A (n = 12) received a single intracoronary infusion of BMC (1.9 +/- 1.2 x 10(8)) at 3-7 days after AMI; Group B (n = 15) received BMC administration both at 3-7 days (2.0 +/- 1.4 x 10(8)) and at 3 months (2.1 +/- 1.7 x 10(8)); and the control group (CON, n = 12) received one placebo injection at 3-7 days. We noted no severe complications associated with the BMC transfer. The increase in LVEF evaluated by magnetic resonance imaging (MRI) after 12 months in Group B (11.7 +/- 2.6%) was significantly greater than that in Group A (7.2 +/- 1.6%, P < 0.001) or in CON (2.9 +/- 2.0%, P < 0.001). Magnetic resonance imaging-derived myocardial infarct size decreased significantly in Group B compared with Group A (11.3 +/- 2.7% vs. 6.3 +/- 1.6%, P < 0.001).
CONCLUSION: Data from this preliminary study suggest that repeated BMC administration might be a safe and feasible therapeutic strategy for patients with large AMI.
Kang Yao; Rongchong Huang; Aijun Sun; Juying Qian; Xuebo Liu; Lei Ge; Yiqi Zhang; Shuning Zhang; Yuhong Niu; Qibing Wang; Yunzeng Zou; Junbo Ge
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-05-06
Journal Detail:
Title:  European journal of heart failure     Volume:  11     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-25     Completed Date:  2010-09-21     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  691-8     Citation Subset:  IM    
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
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MeSH Terms
Analysis of Variance
Angioplasty, Balloon, Coronary
Bone Marrow Transplantation / methods*
Bundle-Branch Block
Confidence Intervals
Magnetic Resonance Imaging
Middle Aged
Myocardial Infarction / mortality,  physiopathology,  therapy*
Time Factors
Tomography, Emission-Computed, Single-Photon
Transplantation, Autologous
Treatment Outcome
Ventricular Function, Left / physiology
Young Adult

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