| Repeated anaesthesia with isoflurane and xylazine/levomethadone/fenpipramide premedication in female Beagle dogs: influence on general health and wellbeing. | |
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MedLine Citation:
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PMID: 18782826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Beagle dogs continue to be used in experimental studies and preclinical and clinical trials, many of which address the usage of anaesthesia. In order to reduce the number of animals, researchers tend to conduct several experiments on a single animal. The question arises, however, as to whether or not this frequent usage involves more than simply additional stress and discomfort for the individual animal. Within the framework of an existing study involving six female Beagle dogs, we investigated the effects of repeated (5) isoflurane anaesthesia with xylazine/levomethadone/fenpipramide premedication carried out at short intervals (2 weeks) and compared these with the effects of two treatments intermitted by a longer resting period (8 weeks). To verify our hypothesis that frequent anaesthesia affects the dog's wellbeing more than the occasional anaesthesia, the following parameters were measured at regular intervals: body weight, body temperature, respiratory rate, blood pressure, reflexes and heart rate, both at rest and during a treadmill exercise. In addition, recovery behaviour subsequent to anaesthesia was monitored for one hour. Our observations indicate that the anaesthetic effects are most prominent 24 h after the anaesthetic treatment. However, crossover analysis of our data cannot show that there is no statistical difference of whether dogs were anaesthetized occasionally or frequently. In our study, it appears that frequent anaesthesia within a two-week period did not affect the wellbeing and general health of Beagle dogs in a super-additive manner and that a minimum of two-week testing-free period is sufficient to ensure complete recovery from the unwanted effects induced by anaesthesia. |
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Authors:
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B Bert; I Hartje; J-P Voigt; G Arndt; H-F Ulbrich; H Fink; P Hauff |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-09-09 |
Journal Detail:
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Title: Laboratory animals Volume: 42 ISSN: 0023-6772 ISO Abbreviation: Lab. Anim. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-08 Completed Date: 2008-12-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0112725 Medline TA: Lab Anim Country: England |
Other Details:
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Languages: eng Pagination: 473-82 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology and Toxicology, School for Veterinary Medicine, Freie Universität Berlin, 14195 Berlin, Germany. bert.bettina@vetmed.fu-berlin.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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methods,
veterinary* Anesthesia Recovery Period Anesthetics, Inhalation / administration & dosage* Animal Welfare* Animals Animals, Laboratory Blood Pressure / drug effects Body Temperature / drug effects Body Weight / drug effects Cross-Over Studies Diphenylacetic Acids / administration & dosage Dogs / physiology* Female Heart Rate / drug effects Isoflurane / administration & dosage* Methadone / administration & dosage Preanesthetic Medication / veterinary* Respiration / drug effects Xylazine / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Diphenylacetic Acids; 26675-46-7/Isoflurane; 7361-61-7/Xylazine; 76-99-3/Methadone; 77-01-0/fenpipramide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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