Document Detail


Repeated allopregnanolone exposure induces weight gain in schedule fed rats on high fat diet.
MedLine Citation:
PMID:  25484355     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Ingestion of energy rich high fat diets is one of the determining factors associated with the obesity epidemic. Therefore, much can be learned from studies of obesity-related substances given to animals fed a high fat diet. The progesterone metabolite allopregnanolone is a potent positive modulator of the gamma-aminobutyric acid (GABA)A-receptor, and both allopregnanolone and GABA have been implicated in evoking hyperphagia. In this study, food intake and body weight gain were investigated during repeated allopregnanolone exposure. Male Wistar rats were studied when fed chow ad libitum, with chow access for 4h per day or with 45% high fat pellets for 4h per day. Rats on the high fat diet were separated into obesity prone and obesity resistant individuals. Subcutaneous injections of allopregnanolone were given once daily over five consecutive days. Repeated exposure to allopregnanolone lead to increased weight gain, significantly so in schedule fed rats on a high fat diet. The increased weight gain was correlated to an increased energy intake. Both obesity resistant and obesity prone rats responded to allopregnanolone with increased weight gain. Obesity resistant rats treated with allopregnanolone increased their energy intake and ate as much as vehicle treated obesity prone rats. Their weight gain was also increased to the level of obesity prone rats injected with just the vehicle carrier oil. Thus, it appears that allopregnanolone may be one of the endogenous factors involved in weight gain, especially when the diet is rich in fat.
Authors:
E Holmberg; M Johansson; T Bäckström; M Löfgren; D Haage
Related Documents :
3815135 - Effect of changes in dietary energy intake and environmental temperature on heat tolera...
25489405 - Arctiin inhibits adipogenesis in 3t3-l1 cells and decreases adiposity and body weight i...
935005 - Effects of the chicken body louse, menacanthus stramineus, on caged layers.
9800045 - Plasma alkaline phosphatase and production traits in laying hens as influenced by dieta...
11170695 - Wolf spider predator avoidance tactics and survival in the presence of diet-associated ...
21906405 - Impact of perinatal prebiotic consumption on gestating mice and their offspring: a prel...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-4
Journal Detail:
Title:  Physiology & behavior     Volume:  -     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-9     Completed Date:  -     Revised Date:  2014-12-9    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Psychological strain: Examining the effect of hypoxic bedrest and confinement.
Next Document:  Perceived stress and freshman weight change: The moderating role of baseline body mass index.