| Repeated administration of methamphetamine damages cells in the somatosensory cortex: overlap with cytochrome oxidase-rich barrels. | |
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MedLine Citation:
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PMID: 10842349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiple injections of methamphetamine (mAMPH) cause degeneration of neurons in rat primary somatosensory cortex (Par1). These degenerating cells can be labeled histochemically with the fluorochrome dye, Fluoro-Jade (FJ). This area of Par1 also contains the representation of the mystacial vibrissae. Neurons in this area of Par1 receiving projections derived from the vibrissae are arranged in discrete functional units ("barrels"), which are revealed by cytochrome oxidase (CO) histochemistry. Here, rats given mAMPH (four injections of 4 mg/kg, sc, 2-h intervals between injections) showed FJ-positive neurons in Par1 that were located predominantly near the perimeter of the CO-dense barrels. Thus, the Par1 neurons damaged by multiple administration of mAMPH are located within whisker barrels. |
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Authors:
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S J O'Dell; J F Marshall |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Synapse (New York, N.Y.) Volume: 37 ISSN: 0887-4476 ISO Abbreviation: Synapse Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-07-17 Completed Date: 2000-07-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8806914 Medline TA: Synapse Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 32-7 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Wiley-Liss, Inc. |
Affiliation:
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Department of Neurobiology & Behavior, University of California, Irvine 92697, USA. sjodell@uci.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dopamine Uptake Inhibitors / toxicity* Electron Transport Complex IV / metabolism* Male Methamphetamine / toxicity* Nerve Degeneration / chemically induced*, metabolism Neurons / enzymology* Rats Rats, Sprague-Dawley Somatosensory Cortex / cytology*, drug effects Vibrissae / innervation, physiology |
| Grant Support | |
ID/Acronym/Agency:
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DA10249/DA/NIDA NIH HHS; DA12204/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Uptake Inhibitors; 537-46-2/Methamphetamine; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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