Document Detail

Repeated acute stress alters heart morphometry in male and female rats differently.
MedLine Citation:
PMID:  12637209     Owner:  NLM     Status:  MEDLINE    
Stress exerts deleterious effects on the cardiovascular system. Left ventricular hypertrophy has been identified as a risk factor for heart disease. The effects of stress on other heart parameters, including heart size and heart shape, are not well-characterized. In addition, the extent to which males and females differ in stress effects on these measures has not been examined, but may help to further explain gender differences in heart disease morbidity and mortality. The present experiment examined effects of mild daily stress on heart morphology and blood volume (obtained by ex-sanguination at decapitation) in 39 male and 40 female rats of two strains. Following 14 days of stress exposure, rats were killed and blood volume was measured. Heart length, heart weight, left ventricle cavity width, right ventricle width, lateral wall thickness, anterior wall thickness, posterior wall thickness, and septal wall thickness were measured. In males, after controlling for body weight, stress decreased heart length and left ventricle cavity width and increased septal wall thickness. In females, after controlling for body weight, stress reduced total blood volume, but did not significantly affect other heart parameters. These findings suggest that stress exposure can alter heart morphology and blood volume and that there are sex differences in these effects.
Brenda M Elliott; Martha M Faraday; Neil E Grunberg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Stress (Amsterdam, Netherlands)     Volume:  6     ISSN:  1025-3890     ISO Abbreviation:  Stress     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-14     Completed Date:  2003-05-21     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9617529     Medline TA:  Stress     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
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MeSH Terms
Acute Disease
Blood Volume
Myocardium / pathology*
Rats, Long-Evans
Rats, Sprague-Dawley
Sex Characteristics*
Stress, Physiological / etiology,  pathology*,  physiopathology

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