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Repeated Restraint Stress Reduces the Number of IgA-Producing Cells in Peyer's Patches.
MedLine Citation:
PMID:  21212701     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The few reports that have analyzed the effects of stress on the immune cells of the intestinal mucosa or the functions of these cells have tended to focus on S-IgA levels in saliva, and these studies have shown contradictory results. The principal objective of this study was to analyze the effects of repeated restraint stress on the number and distribution of immune cells in Peyer's patches (PPs) as well as the effects of glucocorticoid and catecholamine administration on the same stress-related parameters. Upon analyzing the effect of repeated restraint stress on PPs, it was found that there was no modification in the morphological structure of the PPs but that restraint stress reduced the total number of lymphocytes and the number of CD8+ T cells, B cells, and plasma cells in PPs. Only at the site of PPs where IgA-producing plasma cells are most numerous (the dome) was a decrease found in this type of cell. These effects were due at least in part to the effect of glucocorticoids and catecholamines. Since IgA produced in PPs is a natural antibody that impedes bacterial infections, repeated stress may favor the entry of pathogens through the intestine.
Authors:
Beatriz Elina Martínez-Carrillo; Marycarmen Godinez-Victoria; Adriana Jarillo-Luna; Rigoberto Oros-Pantoja; Edgar Abarca-Rojano; Víctor Rivera-Aguilar; Judith Pacheco Yépez; Luvia Enid Sánchez-Torres; Rafael Campos-Rodríguez
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-06
Journal Detail:
Title:  Neuroimmunomodulation     Volume:  18     ISSN:  1423-0216     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422763     Medline TA:  Neuroimmunomodulation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  131-141     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Departamento de Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina-IPN, México, México.
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