Document Detail


Repeated Haloperidol Administration has No Effect on Vitamin D Signaling but Increase Retinoid X Receptors and Nur77 Expression in Rat Prefrontal Cortex.
MedLine Citation:
PMID:  23324997     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Both vitamin D (VD) signaling and Nur77 are implicated in dopaminergic neurotransmission and dopamine-related neuropsychiatric disorders, such as schizophrenia and Parkinson's disease. Developmental vitamin D (DVD) deficiency rats exhibit schizophrenia-like behaviors and disturbance of dopamine system, which could be partly normalized by haloperidol treatment. By blocking dopamine D(2) receptor, haloperidol induces Nur77 expression, suggesting a modulatory role of Nur77 in brain dopamine system. Rxr is the heterodimeric partner of both Nur77 and vitamin D receptor and also participates in homeostatic regulation of central dopamine neurotransmission. Although D(2) antagonist-induced Nur77 expression has been reported by several studies, the change of its active partner Rxr remains elusive. Here, we studied the impact of 2 weeks administration of haloperidol on VD signaling and Nur77/Rxr expression in rat prefrontal cortex. It was found that haloperidol has no effect on local VD signaling, but could significantly increase Nur77, Rxr(β), and Rxr(γ) expression, which indicated that Nur77/Rxr, but not vdr/Rxr, was implicated in dopamine-related neuroadaptation. Given that VD deficiency is commonly observed in schizophrenia patients, the renal metabolism of VD was also examined.
Authors:
Pei Jiang; Wen-Yuan Zhang; Huan-De Li; Hua-Lin Cai; Ying Xue
Related Documents :
19959837 - Nanoscale imaging of epidermal growth factor receptor clustering: effects of inhibitors.
8106877 - Expression of ngf-receptors during immune-mediated and lysolecithin-induced demyelinati...
24250787 - Impact of polymorphic variants on the molecular pharmacology of the two-agonist conform...
21414307 - Beneficial estrogen-like effects of ginsenoside rb1(,) an active component of panax gin...
20371317 - Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion ch...
11137757 - Butanol effects on gamma-amino butyric acid concentration-responses in human alpha1beta...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Cellular and molecular neurobiology     Volume:  -     ISSN:  1573-6830     ISO Abbreviation:  Cell. Mol. Neurobiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200709     Medline TA:  Cell Mol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital, Central South University, 139 Renmin road, Changsha, 410011, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  ATP2B1 and blood pressure: from associations to pathophysiology.
Next Document:  Retinal Cell Death Induced by TRPV1 Activation Involves NMDA Signaling and Upregulation of Nitric Ox...