Document Detail


Repeated DNA sequences in the distal long arm of the human X chromosome.
MedLine Citation:
PMID:  3019869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two DNA probes from within a single large insert from a recombinant phage-DNA library that was constructed from flow-sorted chromosomes enriched for the human X chromosome were shown to hybridize with repeated X-specific and autosomal DNA sequences. The X-chromosomal repeated sequences were assigned to the distal long arm of the X chromosome by both hybrid mapping and in situ hybridization. Fine mapping places these repeats in a region of Xq28 between DX13 (DXS15, in distal Xq28) and factor VIII (F8C, in proximal Xq28). The location of the X-specific repeats makes them potentially useful for future investigations of diseases mapping to the distal long arm of the X chromosome, such as the fragile X syndrome.
Authors:
U Müller; U Tantravahi; A Monaco; H Stroh; L M Kunkel; S A Latt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human genetics     Volume:  74     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-30     Completed Date:  1986-10-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Chromosome Mapping
Cricetinae
Cricetulus
DNA / genetics
DNA Restriction Enzymes
Deoxyribonuclease HindIII
Humans
Hybrid Cells
Nucleic Acid Hybridization
Repetitive Sequences, Nucleic Acid*
X Chromosome*
Grant Support
ID/Acronym/Agency:
GM33579/GM/NIGMS NIH HHS; HD 18658/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9007-49-2/DNA; EC 3.1.21.-/DNA Restriction Enzymes; EC 3.1.21.-/Deoxyribonuclease HindIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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