Document Detail

Repeatability of spectral components of short-term blood pressure and heart rate variability during acute sympathetic activation in healthy young male subjects.
MedLine Citation:
PMID:  9279199     Owner:  NLM     Status:  MEDLINE    
1. Changes in the low-frequency (LF) components of blood pressure and heart rate variability and in the ratio of LF to high-frequency (HF) components of heart rate variability (LF/HF ratio) are used to assess acute changes in sympathetic control of blood pressure or heart rate and in sympathovagal balance that occur in response to physiological or pharmacological stimuli. Before these spectral indexes can be used to assess the effects of drug therapy or other clinical interventions on reflex sympathetic activity, their repeatability must be evaluated. 2. Intra-observer repeatability was studied by analysing changes in the LF components (expressed as absolute or normalized units) of cardiovascular variability and in the LF/HF ratio during sympathetic activation induced by nitroglycerin infusion (n = 10 subjects) or 60 degrees head-up tilt (n = 13 subjects) repeated on two occasions, 2 days and 1 week apart respectively, in healthy young male volunteers. Repeatability was estimated as recommended by Bland and Altman. 3. Bland and Altman's plots of the repeatability of changes in the LF components and LF/HF ratio showed that measurements were sufficiently repeatable to be used over periods of time of up to 1 week in clinical studies. 4. The sample-size tables derived from our results show that expression of spectral components as normalized units, and use of a cross-over design, minimize the number of subjects to be included in clinical studies conducted using similar designs and LF component changes as endpoints.
L Cloarec-Blanchard; C Funck-Brentano; M Lipski; P Jaillon; I Macquin-Mavier
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  93     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-09     Completed Date:  1997-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  21-8     Citation Subset:  IM; S    
Department of Clinical Pharmacology, Henri Mondor University Hospital, Creteil, France.
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MeSH Terms
Blood Pressure / physiology*
Heart Rate / physiology*
Nitroglycerin / diagnostic use*
Observer Variation
Reproducibility of Results
Signal Processing, Computer-Assisted*
Stimulation, Chemical
Sympathetic Nervous System / drug effects*
Vasodilator Agents / diagnostic use*
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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