| Repeatability of short-duration transient visual evoked potentials in normal subjects. | |
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MedLine Citation:
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PMID: 20111979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the within-session and inter-session repeatability of a new, short-duration transient visual evoked potential (SD-tVEP) device on normal individuals, we tested 30 normal subjects (20/20 visual acuity, normal 24-2 SITA Standard VF) with SD-tVEP. Ten of these subjects had their tests repeated within 1-2 months from the initial visit. Synchronized single-channel EEG was recorded using a modified Diopsys Enfant System (Diopsys, Inc., Pine Brook, New Jersey, USA). A checkerboard stimulus was modulated at two reversals per second. Two different contrasts of checkerboard reversal patterns were used: 85% Michelson contrast with a mean luminance of 66.25 cd/m(2) and 10% Michelson contrast with a mean luminance of 112 cd/m(2). Each test lasted 20 s. Both eyes, independently and together, were tested 10 times (5 times at each contrast level). The following information was identified from the filtered N75-P100-N135 complex: N75 amplitude, N75 latency, P100 amplitude, P100 latency, and Delta Amplitude (N75-P100). The median values for each eye's five SD-tVEP parameters were calculated and grouped into two data sets based on contrast level. Mean age was 27.3 +/- 5.2 years. For OD only, the median (95% confidence intervals) of Delta Amplitude (N75-P100) amplitudes at 10% and 85% contrast were 4.6 uV (4.1-5.9) and 7.1 uV (5.15-9.31). The median P100 latencies were 115.2 ms (112.0-117.7) and 104.0 ms (99.9-106.0). There was little within-session variability for any of these parameters. Intraclass correlation coefficients ranged between 0.64 and 0.98, and within subject coefficients of variation were 3-5% (P100 latency) and 15-30% (Delta Amplitude (N75-P100) amplitude). Bland-Altman plots showed good agreement between the first and fifth test sessions (85% contrast Delta Amplitude (N75-P100) delta amplitude, mean difference, 0.48 mV, 95% CI, -0.18-1.12; 85% contrast P100 latency delay, -0.82 ms, 95% CI, -3.12-1.46; 10% contrast Delta Amplitude (N75-P100) amplitude, 0.58 mV, 95% CI, -0.27-1.45; 10% contrast P100 latency delay, -2.05 mV, 95% CI, -5.12-1.01). The inter-eye correlation and agreement were significant for both SD-tVEP amplitude and P100 latency measurements. For the subset of eyes in which the inter-session repeatability was tested, the intraclass correlation coefficients ranged between 0.71 and 0.86 with good agreement shown on Bland-Altman plots. Short-duration transient VEP technology showed good within-session, inter-session repeatability, and good inter-eye correlation and agreement. |
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Authors:
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Celso Tello; Carlos Gustavo V De Moraes; Tiago S Prata; Peter Derr; Jayson Patel; John Siegfried; Jeffrey M Liebmann; Robert Ritch |
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Publication Detail:
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Type: Journal Article Date: 2010-01-29 |
Journal Detail:
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Title: Documenta ophthalmologica. Advances in ophthalmology Volume: 120 ISSN: 1573-2622 ISO Abbreviation: Doc Ophthalmol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-13 Completed Date: 2010-08-31 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 0370667 Medline TA: Doc Ophthalmol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 219-28 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Einhorn Clinical Research Center, New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA. doctorcelsotello@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Electroencephalography Electrophysiology Evoked Potentials, Visual / physiology* Female Humans Male Reference Values Reproducibility of Results Visual Acuity / physiology |
| Comments/Corrections | |
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