| Repeatability of left ventricular ejection fraction and volume measurement for 99mTc-tetrofosmin gated single photon emission computed tomography (SPECT). | |
| | |
MedLine Citation:
|
PMID: 15753794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: This study was carried out to assess the repeatability of left ventricular ejection fraction (EF) and volume values obtained using Cedars-Sinai quantitative gated single photon emission computed tomography (SPECT) (QGS) software and relatively low doses of 400-600 MBq of 99mTc-tetrofosmin. METHODS: Repeatability was assessed in a group of 75 patients, with both normal and reduced EF, who underwent repeat 99mTc-tetrofosmin gated SPECT studies and showed no clinical change in cardiac status. Gated SPECT data were acquired 1 h after injection at rest of 400-600 MBq of 99mTc-tetrofosmin. The standard patient dose was 400 MBq; however, some patients with a weight of >90 kg were given increased doses up to a maximum of 600 MBq. RESULTS: There was good correlation of EF and volumes between the first and repeat measurements, and no significant difference between the mean EF and volumes for both the initial and repeat measurements. Background-corrected counts in the left ventricle were calculated and patients were divided into two groups: one with low counts and one with high counts. The mean difference in EF between the first and repeat measurements was significantly higher for patients in the low count group compared with those in the high count group, but there was no significant change in volume. Similarly, the mean sequential difference in EF was significantly higher for patients with normal EF, but there was no significant difference in volume. CONCLUSIONS: We have demonstrated that EF measured using 99mTc-tetrofosmin gated SPECT is repeatable, particularly for patients with low EF, provided that adequate left ventricular counts are obtained. This will require doses greater than 400 MBq in larger patients. Ventricular volumes calculated using QGS may not be sufficiently repeatable for clinical use. |
| | |
Authors:
|
Penelope J Thorley; Jennifer M Smith |
Related Documents
:
|
12804724 - Individual prediction of functional recovery after coronary revascularization in patien... 8524704 - Right ventricular size and function as assessed by echocardiography and angiography in ... 7357724 - Evaluation of aortic valve replacement in patients with valvular aortic stenosis. 8682084 - Subclassification of dilated cardiomyopathy and interferon treatment. 7433934 - Circumclusion of atrial septal defect in elderly patients. 17251884 - Cisatracurium in "weakening doses" assists in weaning from sedation and withdrawal foll... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Validation Studies |
Journal Detail:
|
Title: Nuclear medicine communications Volume: 26 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2005 Apr |
Date Detail:
|
Created Date: 2005-03-08 Completed Date: 2005-07-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
|
Languages: eng Pagination: 345-9 Citation Subset: IM |
Affiliation:
|
Nuclear Cardiology Department, The General Infirmary at Leeds, Leeds, UK. pjt@medphysics.leeds.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Female Humans Image Interpretation, Computer-Assisted / methods* Male Middle Aged Myocardial Infarction / complications, radionuclide imaging* Organophosphorus Compounds / diagnostic use* Organotechnetium Compounds / diagnostic use* Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Software Validation Stroke Volume* Tomography, Emission-Computed, Single-Photon / methods* Ventricular Dysfunction, Left / etiology, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
|
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The identification of reversible dysfunctional myocardium is influenced by the severity of contracti...
Next Document: Agreement between four available algorithms to evaluate global systolic left and right ventricular f...