Document Detail

Repeatability of cold pressor test-induced flow increase assessed with H(2)(15)O and PET.
MedLine Citation:
PMID:  16954548     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the repeatability of endothelium-related myocardial blood flow (MBF) responses to cold pressor testing (CPT) as assessed by PET. METHODS: In 10 age-matched control subjects (26.6 +/- 3.4 y) and 10 tobacco smokers (24.9 +/- 3.3 y) MBF was assessed at rest and after repeated CPT (CPT1 and CPT2, 40 min apart) using PET with H(2)(15)O. CPT was performed by a 2-min immersion of the subject's foot in ice water. MBF values were corrected for cardiac workload (rate.pressure product), and the repeatability of CPT-related MBF values was assessed according to Bland and Altman. RESULTS: Corrected MBF at CPT1 and CPT2 were comparable in control subjects (1.79 +/- 0.37 vs. 1.70 +/- 0.35 mL/min/g; P = not significant [NS]) and in smokers (1.97 +/- 0.42 vs. 1.80 +/- 0.41 mL/min/g; P = NS). Repeatability coefficients in control subjects and smokers were 0.46 mL/min/g (27% of the mean MBF) and 0.51 mL/min/g (27%), respectively. MBF increased significantly after CPT in both groups but tended to be lower in smokers (P = 0.08). CONCLUSION: PET measured MBF combined with CPT is a feasible and repeatable method for the evaluation of endothelium-related changes of MBF.
Patrick T Siegrist; Oliver Gaemperli; Pascal Koepfli; Tiziano Schepis; Mehdi Namdar; Ines Valenta; Floreana Aiello; Samuel Fleischmann; Hatem Alkadhi; Philipp A Kaufmann
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  47     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-06     Completed Date:  2006-10-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1420-6     Citation Subset:  IM    
Nuclear Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland.
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MeSH Terms
Blood Flow Velocity
Cold Temperature / diagnostic use*
Coronary Artery Disease / radionuclide imaging
Coronary Circulation*
Coronary Vessels / physiopathology*,  radionuclide imaging*
Endothelium, Vascular / radionuclide imaging
Exercise Test / methods
Oxygen Radioisotopes / diagnostic use
Positron-Emission Tomography / methods*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Smoking / physiopathology*
Vasomotor System / physiopathology
Water / diagnostic use*
Reg. No./Substance:
0/Oxygen Radioisotopes; 0/Radiopharmaceuticals; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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