Document Detail


Repeat resection of pulmonary metastasis is beneficial for patients with osteosarcoma of the extremities.
MedLine Citation:
PMID:  19640866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary metastasectomy in osteosarcoma can lead to long-term survival, but the role for repeat pulmonary metastasectomy is undefined. To confirm the value of repeat pulmonary resection of recurrent pulmonary metastases, we herein reviewed our institutional experience. Between 1989 and 2007, 25 patients with pulmonary metastases from osteosarcomas of the extremities underwent pulmonary resection, and 14 patients underwent repeat pulmonary metastasectomy. Ten of 14 patients underwent complete resection. Various perioperative variables were investigated retrospectively in these patients to confirm a role for repeat metastasectomy and analyze prognostic factors for overall survival (OS) after repeat pulmonary metastasectomy. OS rate after repeat pulmonary metastasectomy was 43% at two years and 19% at five years. On multivariate analysis, patients with complete resection presented significantly favorable OS (P=0.02). Interestingly enough, survival curve of patients with complete resection after the first pulmonary metastasectomy was almost the same as that of patients with complete resection after the second pulmonary metastasectomy. In conclusion, patients with complete resection for recurrent pulmonary metastasis show a significantly better prognosis after repeat pulmonary metastasectomy. Our data imply that repeat pulmonary metastasectomy might be beneficial because it can salvage a subset of patients with osteosarcoma who retain favorable prognostic determinants.
Authors:
Fengshi Chen; Ryo Miyahara; Toru Bando; Kenichi Okubo; Kenichiro Watanabe; Tomitaka Nakayama; Junya Toguchida; Hiroshi Date
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Publication Detail:
Type:  Journal Article     Date:  2009-07-29
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  9     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-23     Completed Date:  2009-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  649-53     Citation Subset:  IM    
Affiliation:
Department of Thoracic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bone Neoplasms / mortality,  pathology*
Child
Extremities
Female
Humans
Kaplan-Meiers Estimate
Lung Neoplasms / mortality,  secondary,  surgery*
Male
Middle Aged
Osteosarcoma / mortality,  secondary,  surgery*
Pneumonectomy*
Proportional Hazards Models
Reoperation
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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