Document Detail

Repeat intra-arterial papaverine for recurrent cerebral vasospasm after subarachnoid haemorrhage.
MedLine Citation:
PMID:  9351116     Owner:  NLM     Status:  MEDLINE    
We assessed the prevalence of recurrent vasospasm following failure of intra-arterial papaverine and the efficacy of repeat intra-arterial infusions of papaverine for control of recurrent vasospasm. Of 24 patients treated with intra-arterial papaverine for vasospasm following aneurysm surgery, 12 did not improve clinically after the initial treatment; 9 received second or third infusions on consecutive days; 6 received only a second infusion; and 3 received a third. Superselective infusion into the intracranial arteries was performed in all nine cases. Despite angiographic improvement after the initial or second infusions, all nine patients showed varying degrees of recurrent vasospasm at the time of the second or third treatment. Within 24 h of a second infusion, three of the six patients had significant clinical improvement, and one of these showed marked improvement soon after a third infusion. Our preliminary results suggest that repeat papaverine infusion may be a way of controlling recurrent or recalcitrant vasospasm.
Y Numaguchi; G H Zoarski; J E Clouston; M T Zagardo; J M Simard; E F Aldrich; M A Sloan; P K Maurer; S H Okawara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroradiology     Volume:  39     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-16     Completed Date:  1997-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  751-9     Citation Subset:  IM    
Department of Radiology, University of Rochester Medical Center, NY 14642, USA.
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MeSH Terms
Cerebral Angiography / drug effects
Injections, Intra-Arterial
Ischemic Attack, Transient / drug therapy*,  radiography
Middle Aged
Papaverine / administration & dosage*
Subarachnoid Hemorrhage / complications*,  radiography
Treatment Outcome
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Vasodilator Agents; 58-74-2/Papaverine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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