| Repeat CT assessed CTV variation and PTV margins for short- and long-course pre-operative RT of rectal cancer. | |
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MedLine Citation:
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PMID: 22239865 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: To quantify the inter-fraction shape variation of the CTV in rectal-cancer patients treated with 5×5 (SCRT) and 25×2Gy (LCRT) and derive PTV margins. METHODS AND MATERIALS: Thirty-three SCRT with daily repeat CT scans and 30 LCRT patients with daily scans during the first week followed by weekly scans were included. The CTV was delineated on all scans and local shape variation was calculated with respect to the planning CT. Margin estimation was done using the local shape variation to assure 95% minimum dose for at least 90% of patients. RESULTS: Using 482 CT scans, systematic and random CTV shape variation was heterogeneous, ranging from 0.2cm close to bony structures up to 1.0cm SD at the upper-anterior CTV region. A significant reduction in rectal volume during LCRT resulted in an average 0.5cm posterior shift of the upper-anterior CTV. Required margins ranged from 0.7cm close to bony structures up to 3.1 and 2.3cm in the upper-anterior region for SCRT and LCRT, respectively. CONCLUSIONS: Heterogeneous shape variation demands anisotropic PTV margins. Required margins were substantially larger in the anterior direction compared to current clinical margins. These larger margins were, however, based on strict delineated CTVs, resulting in smaller PTVs compared to current practice. |
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Authors:
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Jasper Nijkamp; Maurits Swellengrebel; Birgit Hollmann; Rianne de Jong; Corrie Marijnen; Corine van Vliet-Vroegindeweij; Baukelien van Triest; Marcel van Herk; Jan-Jakob Sonke |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology Volume: - ISSN: 1879-0887 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8407192 Medline TA: Radiother Oncol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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