Document Detail


Repairing neural injuries using human umbilical cord blood.
MedLine Citation:
PMID:  23275174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stem cells are promising sources for repairing damaged neurons and glial cells in neural injuries and for replacing dead cells in neurodegenerative diseases. An essential step for stem cell-based therapy is to generate large quantities of stem cells and develop reliable culture conditions to direct efficient differentiation of specific neuronal and glial subtypes. The human umbilical cord and umbilical cord blood (UCB) are rich sources of multiple stem cells, including hematopoietic stem cells, mesenchymal stem cells, unrestricted somatic stem cells, and embryonic-like stem cells. Human UC/UCB-derived cells are able to give rise to multiple cell types of neural lineages. Studies have shown that UCB and UCB-derived cells can survive in injured sites in animal models of ischemic brain damage and spinal cord injuries, and promote survival and prevent cell death of local neurons and glia. Human UCB is easy to harvest and purify. Moreover, unlike embryonic stem cells, the use of human UCB is not limited by ethical quandaries. Therefore, human UCB is an attractive source of stem cells for repairing neural injuries.
Authors:
Tao Sun; Quan-Hong Ma
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-30
Journal Detail:
Title:  Molecular neurobiology     Volume:  47     ISSN:  1559-1182     ISO Abbreviation:  Mol. Neurobiol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-11-11     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8900963     Medline TA:  Mol Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  938-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Fetal Blood / cytology*
Humans
Nerve Regeneration*
Neurons / pathology*
Stem Cell Transplantation*
Stem Cells / cytology
Grant Support
ID/Acronym/Agency:
R01 MH083680/MH/NIMH NIH HHS; R01-MH083680/MH/NIMH NIH HHS
Comments/Corrections

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